Circulating miR-505-5p as a Diagnostic Marker for Acute Cerebral Infarction and Its Predictive Value for Clinical Outcomes After Endovascular Mechanical Thrombectomy.

Abstract

This study aimed to evaluate the diagnostic significance of miR-505-5p in Acute cerebral infarction (ACI) and its prognostic utility following endovascular mechanical thrombectomy. A total of 138 patients with ACI and 120 healthy controls participated. RT-qPCR quantified miR-505-5p levels in serum and cerebrospinal fluid (CSF). The National Institutes of Health Stroke Scale (NIHSS) scores assessed the severity of the disease. Furthermore, the modified Rankin Scale (mRS) score evaluated the prognosis one year after endovascular mechanical thrombectomy. The Pearson coefficient analyzed the correlation between miR-505-5p and NIHSS or mRS scores. Logistic regression determined risk factors associated with poor outcomes. The receiver operating characteristic (ROC) curve assessed diagnostic and prognostic accuracy. miR-505-5p levels in serum and CSF were significantly elevated in ACI patients compared to controls ( P < 0.05). A positive correlation existed between serum miR-505-5p and NIHSS score, which increased with disease severity. miR-505-5p demonstrated 81.88% sensitivity and 85.83% specificity in identifying ACI patients, with levels correlated to mRS scores. Higher levels of miR-505-5p indicated a poor prognosis in ACI patients, suggesting its role as a potential biomarker for adverse outcomes and mortality. Both miR-505-5p and NIHSS scores emerged as risk factors for negative outcomes. Serum miR-505-5p serves as a biomarker for predicting poor prognosis and mortality in patients.In conclusion, elevated serum miR-505-5p may act as a diagnostic biomarker for ACI and correlates with unfavorable prognoses a worse prognosis in patients having endovascular mechanical thrombectomy.