Impact of regional SARS-CoV-2 proceedings on changes in diagnoses of pediatric malignancies in Bavaria during the COVID-19 pandemic.

IF 1.2 4区 医学 Q4 HEMATOLOGY
Pediatric Hematology and Oncology Pub Date : 2024-10-01 Epub Date: 2024-09-05 DOI:10.1080/08880018.2024.2393623
Mira Reger, Kirsi Manz, Theresa Kaeuferle, Ramona Coffey, Zofia Wotschofsky, Irene von Luettichau, Paul-Gerhardt Schlegel, Michael C Frühwald, Selim Corbacioglu, Markus Metzler, Tobias Feuchtinger
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引用次数: 0

Abstract

The COVID-19 pandemic affected daily life significantly and had massive consequences for healthcare systems with tremendous regional differences. This retrospective study aimed to investigate whether the pandemic and resulting societal changes impacted the diagnosis of pediatric malignancies in a distinct region. Pediatric cancer cases in Bavaria (2016-2021) and SARS-CoV-2 proceedings during the peak phase of the pandemic (2020-2021) were retrospectively analyzed. All new diagnoses of pediatric malignancies reported from cancer centers in Bavaria were included. Clinical data from pre-pandemic years was compared to diagnoses made during the pandemic. Official SARS-CoV-2 reports were received from the Bavarian Health and Food Safety Authority and data on regional pandemic measures were obtained from the Healthcare Data Platform. With this design, a comprehensive analysis of the pandemic proceedings was performed. We found significantly decreased incidence-rate ratios for pediatric cancer diagnosis during the early spring peak of SARS-CoV-2 as it was observed in May during the pandemic, followed by non-significantly increased metastatic cancer diagnosis two months later. Additionally, the time-to-diagnosis of pediatric malignancies was significantly prolonged during the pandemic, and outpatient contacts were significantly reduced, although the availability of consultations remained the same. From our findings, we may hypothesize that there have been effects on pediatric cancer diagnosis during the COVID-19 pandemic at vulnerable times. Interpretation of changes remains speculative with potential causes from behavior patterns, such as hesitation, concerns, and potential societal changes during phases of public restrictions, rather than overwhelmed medical capacities. Nevertheless, specific awareness is needed to protect this patient population during potential future pandemics.

COVID-19 大流行期间巴伐利亚地区 SARS-CoV-2 病例对儿科恶性肿瘤诊断变化的影响。
COVID-19 大流行严重影响了人们的日常生活,并对医疗保健系统造成了巨大影响,而且地区之间存在巨大差异。这项回顾性研究旨在调查大流行病及其导致的社会变化是否影响了一个独特地区的儿科恶性肿瘤诊断。研究对巴伐利亚州(2016-2021 年)的儿童癌症病例以及大流行高峰期(2020-2021 年)的 SARS-CoV-2 病例进行了回顾性分析。巴伐利亚州癌症中心报告的所有新诊断的小儿恶性肿瘤病例均包括在内。将大流行前的临床数据与大流行期间的诊断数据进行了比较。巴伐利亚州卫生和食品安全局提供了 SARS-CoV-2 的官方报告,医疗保健数据平台提供了有关地区大流行措施的数据。通过这种设计,我们对大流行过程进行了全面分析。我们发现,在 SARS-CoV-2 初春高峰期,儿科癌症诊断的发病率比明显下降,这与大流行期间 5 月份的情况相同,两个月后,转移性癌症诊断的发病率比明显上升。此外,在大流行期间,儿科恶性肿瘤的诊断时间明显延长,门诊接触明显减少,但就诊人数保持不变。根据我们的研究结果,我们可以推测,在 COVID-19 大流行期间,儿科癌症诊断在易发时段受到了影响。对这些变化的解释仍然是推测性的,其潜在原因来自行为模式,如犹豫不决、担忧以及公共限制阶段的潜在社会变化,而不是医疗能力不堪重负。尽管如此,在未来可能发生的大流行中,我们仍需要特别注意保护这类病人群体。
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来源期刊
CiteScore
2.60
自引率
5.90%
发文量
71
审稿时长
6-12 weeks
期刊介绍: PHO: Pediatric Hematology and Oncology covers all aspects of research and patient management within the area of blood disorders and malignant diseases of childhood. Our goal is to make PHO: Pediatric Hematology and Oncology the premier journal for the international community of clinicians and scientists who together aim to define optimal therapeutic strategies for children and young adults with cancer and blood disorders. The journal supports articles that address research in diverse clinical settings, exceptional case studies/series that add novel insights into pathogenesis and/or clinical care, and reviews highlighting discoveries and challenges emerging from consortia and conferences. Clinical studies as well as basic and translational research reports regarding cancer pathogenesis, genetics, molecular diagnostics, pharmacology, stem cells, molecular targeting, cellular and immune therapies and transplantation are of interest. Papers with a focus on supportive care, late effects and on related ethical, legal, psychological, social, cultural, or historical aspects of these fields are also appreciated. Reviews on important developments in the field are welcome. Articles from scientists and clinicians across the international community of Pediatric Hematology and Oncology are considered for publication. The journal is not dependent on or connected with any organization or society. All submissions undergo rigorous peer review prior to publication. Our Editorial Board includes experts in Pediatric Hematology and Oncology representing a wide range of academic and geographic diversity.
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