A Pilot Study to Test the Feasibility of a Randomized Controlled Trial of E-cigarettes as Harm Reduction Tools Among People Who Smoke and Previously Failed to Quit With Pharmacotherapy.

IF 3 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Nicotine & Tobacco Research Pub Date : 2025-02-24 DOI:10.1093/ntr/ntae212

Tracy T Smith, Anna Ferreira, Amy E Wahlquist, K Michael Cummings, Alana M Rojewski, Erin A McClure, Benjamin A Toll, Matthew J Carpenter

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引用次数: 0

Abstract

Introduction: We conducted a pilot study to test the feasibility of a future randomized controlled trial comparing e-cigarettes to traditional pharmacotherapy among people who smoke daily, were motivated to quit, and failed to quit within the past 5 years using pharmacotherapy.

Aims and methods: Eligible participants were assigned to either: (1) an e-cigarette (n = 20) or (2) combination nicotine replacement therapy (NRT; patches and lozenges; n = 10). Participants received 5 weeks of product and selected a quit date 1 week later. Assessments were completed weekly, and electronic diaries were completed each day. As a pilot randomized controlled trial, outcomes focus on effect sizes and not statistical significance.

Results: Participants in the e-cigarette and NRT groups had a mean age of 51 (SD = 13) and 50 (SD = 10) years old, were 55% and 60% female, and were 15% and 0% nonWhite, respectively. At least 90% of participants completed each weekly assessment and 77% of participants completed at least 80% of daily diaries. Mean cigarettes smoked per day reduced from 18 (SD = 6.2) to 2.4 (SD = 4.4) per day in the e-cigarette group and 16.5 (SD = 8.5) to 4.9 (SD = 5.9) per day in the NRT group. Rates of biochemically confirmed 7-day point-prevalence abstinence at the end of treatment were numerically, but not statistically, higher in the e-cigarette group than the NRT group (35% vs. 10%, OR = 4.8, 95% CI = 0.5 to 46.5).

Conclusions: Among current daily cigarette smokers who have previously tried to quit and failed with standard pharmacotherapies, the provision of an e-cigarette is a feasible intervention. A larger adequately powered trial is warranted.

Implications: This pilot study suggests that e-cigarettes may serve as an acceptable harm reduction intervention for people who smoke but cannot quit smoking with traditional pharmacotherapy, however, adequately powered randomized controlled trials are needed.

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测试将电子烟作为药物疗法戒烟失败者的减害工具进行随机对照试验的可行性的试点研究》（A Pilot Study to Test the Feasibility for a Randomized Controlled Trial of E-cigarettes as Harm Reduction Tools Among People Who Smoke and Previously Fails to Quit with Pharmacotherapy）。

简介：我们开展了一项试点研究，以测试未来随机对照试验的可行性：我们开展了一项试点研究，以测试未来随机对照试验的可行性，该试验将在每天吸烟、有戒烟动机且在过去5年内使用药物疗法未能戒烟的人群中进行，并将电子烟与传统药物疗法进行比较：方法：符合条件的参与者被分配到以下两种方案中：1）电子烟（20 人）或 2）尼古丁替代组合疗法（贴片和含片）（10 人）。参与者接受为期 5 周的产品治疗，并在 1 周后选择戒烟日期。每周完成一次评估，每天完成电子日记。作为一项试点随机对照试验，试验结果侧重于效果大小，而非统计意义：电子烟组和 NRT 组参与者的平均年龄分别为 51 岁（SD=13）和 50 岁（SD=10），女性比例分别为 55% 和 60%，非白人比例分别为 15% 和 0%。至少90%的参与者完成了每周的评估，77%的参与者完成了至少80%的每日日记。电子烟组的平均吸烟量从每天18支（标度值=6.2）降至2.4支（标度值=4.4），NRT组的平均吸烟量从每天16.5支（标度值=8.5）降至4.9支（标度值=5.9）。在治疗结束时，经生化证实的7天点戒烟率在数量上（35% vs. 10%，OR=4.8，95% CI=0.5-46.5）高于NRT组，但没有统计学意义：对于曾经尝试过戒烟但使用标准药物疗法失败的日常吸烟者，提供电子烟是一种可行的干预措施。结论：对于曾经尝试过戒烟但使用标准药物治疗失败的当前每日吸烟者来说，提供电子烟是一种可行的干预措施：这项试点研究表明，对于无法通过传统药物疗法戒烟的吸烟者来说，电子烟可能是一种可接受的减低危害干预措施，但还需要进行充分有效的随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nicotine & Tobacco Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

8.10

自引率

10.60%

发文量

268

审稿时长

3-8 weeks

期刊介绍： Nicotine & Tobacco Research is one of the world''s few peer-reviewed journals devoted exclusively to the study of nicotine and tobacco. It aims to provide a forum for empirical findings, critical reviews, and conceptual papers on the many aspects of nicotine and tobacco, including research from the biobehavioral, neurobiological, molecular biologic, epidemiological, prevention, and treatment arenas. Along with manuscripts from each of the areas mentioned above, the editors encourage submissions that are integrative in nature and that cross traditional disciplinary boundaries. The journal is sponsored by the Society for Research on Nicotine and Tobacco (SRNT). It publishes twelve times a year.