Disorders of gut-brain interaction are common diagnoses among infants and toddlers in gastroenterology practices in Latin America.

IF 2.4 3区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Journal of Pediatric Gastroenterology and Nutrition Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI:10.1002/jpn3.12359

Carlos A Velasco-Benítez, Maura Alvarez-Baumgartner, Claudia J Ortiz-Rivera, Daniela A Velasco-Suárez, Fátima A Reynoso Zarzosa, Mariana X Espriu Ramírez, Jorge A Macías-Flores, Roberto A Zablah Córdova, Ricardo A Chanis Águila, Milton D Mejía Castro, Yunuen Rivera Suazo, Amber N Balda, Miguel Saps

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引用次数: 0

Abstract

Objectives: To assess the relative frequency and associated factors of disorders of gut-brain interaction (DGBIs) in outpatient gastrointestinal (GI) clinics in young children of Latin America.

Methods: Cross-sectional study in 10 pediatric GI outpatient clinics (private and public) in five countries of Latin America (El Salvador, México, Colombia, Panamá, and Nicaragua). Parents of patients 1 month 4 years of age from outpatient clinics complete/d a diagnostic questionnaire for DGBIs per Rome IV criteria (QPGS-IV, Spanish version). We conducted descriptive analysis, two-sample t-tests and chi-square tests, univariate analyses, and logistic regression to evaluate risk factors.

Results: We collected data from 783 children. In total, 34.5% had a DGBI. Overall, functional constipation (FC) was the most common diagnosis (23.4%) in children of all ages (infants, 16.1%, 1-4-years-old, 32.7%). In infants, the second most common DGBI was regurgitation (6.6%) and in 1-4-years-old and cyclic vomiting syndrome (4.1%). The diagnosis of a DGBI was significantly associated with a family history of DGBIs (odds ratio [OR] 2.97, 95% confidence interval [CI] 1.61-5.57, p = 0.0001). Patients who identified as black (OR 2.25, 95% CI 1.28-3.92, p = 0.0021) or mixed race (OR 1.76, 95% CI 1.25-2.48, p = 0.0006) were also significantly associated with a higher likelihood of DGBIs.

Conclusions: DGBIs are a common diagnosis in pediatric GI clinics of Latin America. Overall, FC was the most common DGBI.

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在拉丁美洲，肠道与大脑相互作用失调是婴幼儿胃肠病诊疗中的常见诊断。

目的：评估拉丁美洲幼儿胃肠道门诊中肠道-大脑相互作用紊乱（DGBIs）的相对频率和相关因素：评估拉丁美洲幼儿胃肠（GI）门诊中肠道-大脑相互作用紊乱（DGBIs）的相对频率和相关因素：在拉丁美洲五个国家（萨尔瓦多、墨西哥、哥伦比亚、巴拿马和尼加拉瓜）的 10 家儿科胃肠门诊诊所（私立和公立）进行横断面研究。门诊中 1 个月至 4 岁患者的家长根据罗马 IV 标准填写了 DGBIs 诊断问卷（QPGS-IV，西班牙文版）。我们进行了描述性分析、双样本 t 检验和卡方检验、单变量分析和逻辑回归，以评估风险因素：我们收集了 783 名儿童的数据。共有 34.5% 的儿童患有 DGBI。总体而言，功能性便秘（FC）是各年龄段儿童（婴儿，16.1%；1-4 岁，32.7%）最常见的诊断（23.4%）。在婴儿中，第二常见的 DGBI 是反胃（6.6%），在 1-4 岁儿童中，第二常见的 DGBI 是周期性呕吐综合征（4.1%）。DGBI的诊断与DGBI家族史明显相关（几率比[OR]2.97，95%置信区间[CI]1.61-5.57，P = 0.0001）。黑人（OR 2.25，95% CI 1.28-3.92，p = 0.0021）或混血儿（OR 1.76，95% CI 1.25-2.48，p = 0.0006）也与较高的 DGBIs 可能性显著相关：结论：DGBIs是拉丁美洲儿科消化道诊所的常见诊断。总的来说，FC 是最常见的 DGBI。

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来源期刊

Journal of Pediatric Gastroenterology and Nutrition 医学-胃肠肝病学

CiteScore

5.30

自引率

13.80%

发文量

467

审稿时长

3-6 weeks

期刊介绍： The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.