Synthetic Biology-Driven Microbial Therapeutics for Disease Treatment.

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Journal of microbiology and biotechnology Pub Date : 2024-10-28 Epub Date: 2024-08-19 DOI:10.4014/jmb.2407.07004
Tae Hyun Kim, Byung Kwan Cho, Dae-Hee Lee
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引用次数: 0

Abstract

The human microbiome, consisting of microorganisms that coexist symbiotically with the body, impacts health from birth. Alterations in gut microbiota driven by factors such as diet and medication can contribute to diseases beyond the gut. Synthetic biology has paved the way for engineered microbial therapeutics, presenting promising treatments for a variety of conditions. Using genetically encoded biosensors and dynamic regulatory tools, engineered microbes can produce and deliver therapeutic agents, detect biomarkers, and manage diseases. This review organizes engineered microbial therapeutics by disease type, emphasizing innovative strategies and recent advancements. The scope of diseases includes gastrointestinal disorders, cancers, metabolic diseases, infections, and other ailments. Synthetic biology facilitates precise targeting and regulation, improving the efficacy and safety of these therapies. With promising results in animal models, engineered microbial therapeutics provide a novel alternative to traditional treatments, heralding a transformative era in diagnostics and treatment for numerous diseases.

合成生物学驱动的疾病治疗微生物疗法。
人体微生物群由与人体共生的微生物组成,从出生开始就影响着健康。饮食和药物等因素导致的肠道微生物群的改变可能会引发肠道以外的疾病。合成生物学为工程微生物疗法铺平了道路,为治疗各种疾病带来了希望。利用基因编码的生物传感器和动态调控工具,工程微生物可以生产和输送治疗药物、检测生物标记物和控制疾病。本综述按疾病类型对工程微生物疗法进行了分类,强调了创新策略和最新进展。疾病范围包括胃肠道疾病、癌症、代谢性疾病、感染和其他疾病。合成生物学有助于精确靶向和调控,提高这些疗法的疗效和安全性。工程微生物疗法在动物模型中取得了可喜的成果,为传统疗法提供了新的替代方案,预示着众多疾病的诊断和治疗将进入一个变革时代。
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来源期刊
Journal of microbiology and biotechnology
Journal of microbiology and biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MICROBIOLOGY
CiteScore
5.50
自引率
3.60%
发文量
151
审稿时长
2 months
期刊介绍: The Journal of Microbiology and Biotechnology (JMB) is a monthly international journal devoted to the advancement and dissemination of scientific knowledge pertaining to microbiology, biotechnology, and related academic disciplines. It covers various scientific and technological aspects of Molecular and Cellular Microbiology, Environmental Microbiology and Biotechnology, Food Biotechnology, and Biotechnology and Bioengineering (subcategories are listed below). Launched in March 1991, the JMB is published by the Korean Society for Microbiology and Biotechnology (KMB) and distributed worldwide.
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