FIB-4 Index and Liver Stiffness Measurement are Potential Predictors of Atherosclerosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

IF 3 2区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of atherosclerosis and thrombosis Pub Date : 2024-09-04 DOI:10.5551/jat.64809

Yoshihito Kubotsu, Yoshiko Sakamoto, Motoko Tago, Atsuko Chihara, Misa Norita, Chika Inadomi, Kaori Inoue, Hiroki Takayanagi, Kenichi Tanaka, Hiroshi Isoda, Takuya Kuwashiro, Satoshi Oeda, Toshiyasu Shiratori, Keizo Anzai, Koichi Node, Hirokazu Takahashi

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Abstract

Aims: Cardiovascular disease (CVD) is a common cause of death in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Therefore, CVD surveillance is important, but it is not well established. We evaluated the association between liver fibrosis, carotid artery atherosclerosis, and coronary artery stenosis in patients with MASLD.

Methods: Overall, 153 patients with MASLD who underwent carotid artery ultrasound were enrolled. Maximum intima-media thickness including plaques (Max-IMT) was measured by ultrasound. To predict liver fibrosis, liver stiffness was measured by vibration-controlled transient elastography and the fibrosis 4 (FIB-4) index was calculated. Coronary computed tomography angiography was performed to detect coronary artery stenosis based on a Max-IMT of ≥ 1.1 mm.

Results: The median Max-IMT was 1.3 mm, and 63 patients (41.2%) had a Max-IMT of ≥ 1.5 mm. FIB-4 index and liver stiffness was significantly correlated with Max-IMT, respectively (ρ=0.356, p＜0.001, ρ=0.25, p=0.002). Liver stiffness was significantly associated with a Max-IMT of ≥1.5 mm, independent of age. Individuals with higher FIB-4 index had moderate or severe coronary artery stenosis more frequently. Individuals with higher LSM level also had moderate or severe coronary artery stenosis more frequently, especially severe stenosis.

Conclusions: Liver fibrosis parameters were associated with carotid artery atherosclerosis and coronary artery stenosis. Evaluation of liver fibrosis may be useful to identify significant atherosclerosis and coronary artery stenosis in patients with MASLD.

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FIB-4指数和肝脏硬度测量是代谢功能障碍相关性脂肪肝动脉粥样硬化的潜在预测指标

目的：心血管疾病（CVD）是代谢功能障碍相关性脂肪性肝病（MASLD）患者的常见死因。因此，对心血管疾病的监测非常重要，但目前尚未得到很好的证实。我们评估了MASLD患者肝纤维化、颈动脉粥样硬化和冠状动脉狭窄之间的关联：方法：共招募了153名接受颈动脉超声检查的MASLD患者。超声波测量了包括斑块在内的最大内中膜厚度（Max-IMT）。为预测肝纤维化，通过振动控制瞬时弹性成像测量肝脏硬度，并计算纤维化4（FIB-4）指数。根据 Max-IMT ≥ 1.1 毫米的标准，进行冠状动脉计算机断层扫描以检测冠状动脉狭窄：中位 Max-IMT 为 1.3 毫米，63 名患者（41.2%）的 Max-IMT ≥ 1.5 毫米。FIB-4 指数和肝脏硬度分别与 Max-IMT 显著相关（ρ=0.356，p＜0.001；ρ=0.25，p=0.002）。肝硬变与 Max-IMT ≥1.5 mm 显著相关，与年龄无关。FIB-4指数越高的人，冠状动脉中度或重度狭窄的发生率越高。LSM水平越高的人中度或重度冠状动脉狭窄的发生率也越高，尤其是重度狭窄：结论：肝纤维化参数与颈动脉粥样硬化和冠状动脉狭窄有关。评估肝纤维化可能有助于鉴别MASLD患者的明显动脉粥样硬化和冠状动脉狭窄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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