Sana Ahsan, Saba Jafarpour, Mellad M Khoshnood, Deepti Nagesh, Eugenia Ho, Nusrat Ahsan, Jonathan D Santoro
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引用次数: 0
Abstract
Epstein-Barr virus meningoencephalitis is a rare central nervous system infection that lacks standardized treatment. Immunocompetent and immunosuppressed individuals with this condition frequently have poor prognostic outcomes, making the need to identify therapeutic interventions high. Here, we report 2 pediatric cases of severe Epstein-Barr virus meningoencephalitis, both unresponsive to immunoglobulin and corticosteroid therapy, who demonstrated rapid clinical recovery following rituximab administration. Prognostic outcomes revealed marked improvements in symptoms, neurologic function, and quality of life. Rituximab may offer therapeutic potential in severe and refractory Epstein-Barr virus meningoencephalitis through the medication's target of Epstein-Barr virus harboring B cells. This report emphasizes the need for timely evaluation and consideration of rituximab therapy in immunocompetent pediatric patients with Epstein-Barr virus meningoencephalitis.
Epstein-Barr 病毒脑膜脑炎是一种罕见的中枢神经系统感染，缺乏标准化治疗。免疫功能正常和免疫抑制的患者往往预后不佳，因此亟需确定治疗干预措施。在此，我们报告了两例严重的爱泼斯坦-巴氏病毒脑膜脑炎儿科病例，这两例患者对免疫球蛋白和皮质类固醇治疗均无反应，但在使用利妥昔单抗后临床症状迅速恢复。预后结果显示，患者的症状、神经功能和生活质量明显改善。利妥昔单抗可通过靶向携带爱泼斯坦-巴氏病毒的 B 细胞，为重症和难治性爱泼斯坦-巴氏病毒脑膜脑炎提供治疗潜力。本报告强调了及时评估和考虑利妥昔单抗治疗免疫功能正常的小儿爱泼斯坦-巴氏病毒脑膜脑炎患者的必要性。
期刊介绍：
The Journal of Child Neurology (JCN) embraces peer-reviewed clinical and investigative studies from a wide-variety of neuroscience disciplines. Focusing on the needs of neurologic patients from birth to age 18 years, JCN covers topics ranging from assessment of new and changing therapies and procedures; diagnosis, evaluation, and management of neurologic, neuropsychiatric, and neurodevelopmental disorders; and pathophysiology of central nervous system diseases.
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