Causal Relationship Between Autoimmune Arthritis and Temporomandibular Disorders.

IF 3.2 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International dental journal Pub Date : 2024-09-03 DOI:10.1016/j.identj.2024.08.006

Xue-Feng Li, Jun-Wei Cai, Yuan-Yuan Hu, Yu-Ming Niu

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引用次数: 0

Abstract

Objective: Accumulating evidence has indicated a close interrelation between autoimmune arthritis (AA) and temporomandibular disorders (TMD), but the causality is still unclear. The study aimed to explore the causal inference between AA and TMD using a bidirectional Mendelian randomization analysis.

Methods: Online genome-wide association study data on rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis, and TMD were obtained from the FinnGen and IEU databases. Causality was using the inverse variance-weighted method as the primary analysis and supplemented by other methods. Sensitivity analyses, including heterogeneity tests, horizontal pleiotropy tests, and leave-one-out methods, were conducted to investigate the stability and reliability of the results.

Results: The inverse variance-weighted test indicated that several AA types could causally increase the TMD risk, including overall RA (odds ratio [OR] = 1.348, 95% confidence interval [CI] = 1.1232-1.618, P = .001), subtype nRA (OR = 1.118, 95% CI = 1.044-1.197, P = .001), and AS (OR = 1.060, 95% CI = 1.024-1.097, P = .001). Moreover, the causal association of the above combinations has been proven to be stable and reliable using sensitivity and other tests.

Conclusion: These findings suggest that RA and AS might be causally associated with an increased risk of TMD. However, more studies are needed to check the causal effects of AA on TMD and analyse the potential mechanisms further.

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自身免疫性关节炎与颞下颌关节紊乱之间的因果关系

目的：越来越多的证据表明，自身免疫性关节炎（AA）与颞下颌关节紊乱症（TMD）之间存在密切的相互关系，但其因果关系仍不明确。本研究旨在利用双向孟德尔随机分析法探讨 AA 与 TMD 之间的因果推论：方法：从 FinnGen 和 IEU 数据库中获取有关类风湿性关节炎（RA）、强直性脊柱炎（AS）、银屑病关节炎和 TMD 的在线全基因组关联研究数据。因果关系分析以反方差加权法为主，其他方法为辅。为了研究结果的稳定性和可靠性，还进行了敏感性分析，包括异质性检验、水平多向性检验和撇除方法：逆方差加权检验表明，几种 AA 类型可增加 TMD 风险，包括总体 RA（比值比 [OR] = 1.348，95% 置信区间 [CI] = 1.1232-1.618，P = .001）、亚型 nRA（比值比 [OR] = 1.118，95% 置信区间 [CI] = 1.044-1.197，P = .001）和 AS（比值比 [OR] = 1.060，95% 置信区间 [CI] = 1.024-1.097，P = .001）。此外，上述组合的因果关系经敏感性和其他测试证明是稳定可靠的：这些研究结果表明，RA和AS可能与TMD风险增加存在因果关系。结论：这些研究结果表明，RA和AS可能与TMD风险增加有因果关系，但还需要更多的研究来检验AA对TMD的因果影响，并进一步分析其潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International dental journal 医学-牙科与口腔外科

CiteScore

4.80

自引率

6.10%

发文量

159

审稿时长

63 days

期刊介绍： The International Dental Journal features peer-reviewed, scientific articles relevant to international oral health issues, as well as practical, informative articles aimed at clinicians.