First Reported Case of Pure Red Cell Aplasia Related to Sotorasib.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI:10.2169/internalmedicine.3961-24

Katsuhiro Itogawa, Tatsuya Saito, Yuya Nakata, Hikari Amari, Hiroki Tahara, Nozomu Yoshino, Yuki Maeda, Motoko Nomura, Jun Shiihara, Yoshiaki Nagai, Hiromitsu Ohta, Yasuhiro Yamaguchi

引用次数: 0

Abstract

We herein report a 64-year-old man with KRAS^G12C-mutated advanced lung adenocarcinoma previously treated with immune checkpoint inhibitors (ICIs). One month after starting second-line sotorasib treatment, the patient experienced a progressive decline in serum hemoglobin levels. Anemia was accompanied by markedly elevated serum erythropoietin levels and decreased reticulocyte levels. Bone marrow aspiration revealed pure red cell aplasia. No secondary causes other than medication use were identified. Suspected causative drugs were sotorasib and ICIs. Discontinuation of sotorasib for one week improved his anemia; therefore, the causative drug was identified as sotorasib.

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首例报告的与索托拉西布有关的纯红细胞增生症病例

我们在此报告了一名曾接受免疫检查点抑制剂（ICIs）治疗的 64 岁男性 KRASG12C 突变晚期肺腺癌患者。在开始索托拉西布二线治疗一个月后，患者的血清血红蛋白水平出现了进行性下降。贫血伴有血清促红细胞生成素水平明显升高和网织红细胞水平下降。骨髓穿刺显示纯红细胞再生不良。除用药外，未发现其他继发原因。疑似致病药物为索托拉西布和 ICIs。停用索托拉西布一周后，他的贫血症状有所改善；因此，确定致病药物为索托拉西布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.