Effect of Gegen Qinlian Decoction on the regulation of gut microbiota and metabolites in type II diabetic rats.

IF 4 2区生物学 Q2 MICROBIOLOGY

Frontiers in Microbiology Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI:10.3389/fmicb.2024.1429360

Jinyao Xu, Zhenkai Zou, Xuanyi Li, Xiangjun Sun, Xufeng Wang, Feng Qin, Abulikemu Abulizi, Qian Chen, Zhigang Pan, Hexiao Shen, Yongling Lv, Ruicheng Yan

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Abstract

Gegen Qinlian Decoction (GGQLT) is a traditional Chinese herbal medicine that has been reported to have a significant therapeutic effect in the management of type II diabetes mellitus (T2DM). In this study, we constructed a T2DM rat model by feeding a high-fat diet and injecting streptozotocin (STZ) and tested the effects of feeding GGQLT and fecal transplantation on the physiological indices, microbiota, and metabolism of rats. The results showed that the administration of GGQLT can significantly improve the growth performance of rats and has a remarkable antihyperlipidemic effect. In addition, GGQLT altered the composition of gut microbiota by increasing beneficial bacteria such as Coprococcus, Bifidobacterium, Blautia, and Akkermansia. In addition, GGQLT elevated levels of specific bile acids by metabolomic analysis, potentially contributing to improvements in lipid metabolism. These findings suggest that GGQLT may have beneficial effects on T2DM by influencing lipid metabolism and gut microbiota. However, further studies are needed to elucidate its mechanisms and assess clinical applications.

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格根秦连煎剂对Ⅱ型糖尿病大鼠肠道微生物群和代谢物调节的影响

格根秦连煎（GGQLT）是一种传统中药，据报道对治疗 II 型糖尿病（T2DM）有显著疗效。本研究通过饲喂高脂饮食和注射链脲佐菌素（STZ）构建了 T2DM 大鼠模型，并测试了饲喂 GGQLT 和粪便移植对大鼠生理指标、微生物群和代谢的影响。结果表明，给予 GGQLT 能显著改善大鼠的生长性能，并具有明显的降血脂作用。此外，GGQLT 还能改变肠道微生物群的组成，增加有益菌群，如 Coprococcus、Bifidobacterium、Blautia 和 Akkermansia。此外，通过代谢组分析，GGQLT 提高了特定胆汁酸的水平，这可能有助于改善脂质代谢。这些发现表明，GGQLT 可通过影响脂质代谢和肠道微生物群对 T2DM 产生有益影响。然而，还需要进一步的研究来阐明其机制并评估其临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Microbiology MICROBIOLOGY-

CiteScore

7.70

自引率

9.60%

发文量

4837

审稿时长

14 weeks

期刊介绍： Frontiers in Microbiology is a leading journal in its field, publishing rigorously peer-reviewed research across the entire spectrum of microbiology. Field Chief Editor Martin G. Klotz at Washington State University is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.

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