Quantitative Spermidine Detection in Cosmetics using an Organic Transistor-Based Chemical Sensor

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2024-09-05 DOI:10.1002/open.202400098

Dr. Yui Sasaki, Kohei Ohshiro, Miyuki Kato, Hikaru Tanaka, Akari Yamagami, Dr. Kazutake Hagiya, Prof. Dr. Tsuyoshi Minami

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引用次数: 0

Abstract

Spermidine is an essential biomarker related to antiaging. Although the detection of spermidine levels is in high demand in life science fields, easy-to-use analytical tools without sample purification have not yet been fully established. Herein, we propose an organic field-effect transistor-based chemical sensor for quantifying the spermidine concentration in commercial cosmetics. An extended-gate structure was employed for organic field-effect transistor (OFET)-based chemical sensing in aqueous media. A coordination-bond-based sensing system was introduced into the OFET device to visualize the spermidine detection information through changes in the transistor characteristics. The extended-gate-type OFET has shown quantitative responses to spermidine, which indicates sufficient detectability (i. e., the limit of detection for spermidine: 2.3 μM) considering actual concentrations in cosmetics. The applicability of the OFET-based chemical sensor for cosmetic analysis was validated by instrumental analysis using high-performance liquid chromatography. The estimated recovery rates for spermidine in cosmetic ingredient products (108–111 %) suggest the feasibility of cosmetic analysis based on the OFET-based chemical sensor.

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利用基于有机晶体管的化学传感器定量检测化妆品中的精胺。

精胺是一种与抗衰老相关的重要生物标志物。虽然生命科学领域对精胺含量的检测需求很大，但无需样品纯化的简便分析工具尚未完全建立。在此，我们提出了一种基于有机场效应晶体管的化学传感器，用于量化商业化妆品中的亚精胺浓度。基于有机场效应晶体管（OFET）的化学传感器在水介质中采用了扩展栅结构。在 OFET 器件中引入了基于配位键的传感系统，以通过晶体管特性的变化来显示精胺的检测信息。扩展栅极型 OFET 显示了对亚精胺的定量响应，考虑到化妆品中的实际浓度，这表明它具有足够的可检测性（即亚精胺的检测限：2.3 μM）。通过使用高效液相色谱进行仪器分析，验证了基于 OFET 的化学传感器在化妆品分析中的适用性。化妆品成分产品中亚精胺的估计回收率（108-111%）表明，基于 OFET 化学传感器进行化妆品分析是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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