Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-05 DOI:10.1002/cnr2.70006

Jianxin Guo, Ming Huang, Shuang Hou, Jianfeng Yuan, Xiaoyue Chang, Shuang Gao, Zhenhan Zhang, Zhongbing Wu, Jing Li

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Abstract

Background

In recent decades, natural compounds have been considered a significant source of new antitumor medicines due to their unique advantages. Several in vitro and in vivo studies have focused on the effect of terpenoids on apoptosis mediated by mitochondria in malignant cells.

Recent findings

In this review article, we focused on six extensively studied terpenoids, including sesquiterpenes (dihydroartemisinin and parthenolide), diterpenes (oridonin and triptolide), and triterpenes (betulinic acid and oleanolic acid), and their efficacy in targeting mitochondria to induce cell death. Terpenoid-induced mitochondria-related cell death includes apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and necrosis caused by mitochondrial permeability transition. Apoptosis and autophagy interact in meaningful ways. In addition, in view of several disadvantages of terpenoids, such as low stability and bioavailability, advances in research on combination chemotherapy and chemical modification were surveyed.

Conclusion

This article deepens our understanding of the association between terpenoids and mitochondrial cell death, presenting a hypothetical basis for the use of terpenoids in anticancer management.

Abstract Image

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萜类化合物在癌症治疗中的治疗潜力：针对线粒体途径。

背景：近几十年来，天然化合物因其独特的优势被认为是抗肿瘤新药的重要来源。一些体外和体内研究主要关注萜类化合物对恶性细胞线粒体介导的细胞凋亡的影响：在这篇综述文章中，我们重点研究了六种被广泛研究的萜类化合物，包括倍半萜（二氢青蒿素和分叶肿内酯）、二萜（奥里多宁和三肽内酯）和三萜（白桦脂酸和齐墩果酸），以及它们在靶向线粒体诱导细胞死亡方面的功效。萜类化合物诱导的线粒体相关细胞死亡包括凋亡、热凋亡、坏死、铁凋亡、自噬和线粒体通透性转换引起的坏死。细胞凋亡和自噬以有意义的方式相互作用。此外，鉴于萜类化合物的一些缺点，如稳定性和生物利用度较低，还调查了联合化疗和化学修饰方面的研究进展：本文加深了我们对萜类化合物与线粒体细胞死亡之间关系的理解，为萜类化合物在抗癌治疗中的应用提供了假设基础。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.