Case report: membranoproliferative glomerulonephritis associated with Q fever causing chronic endocarditis.

IF 2.2 4区医学 Q2 UROLOGY & NEPHROLOGY

BMC Nephrology Pub Date : 2024-09-04 DOI:10.1186/s12882-024-03694-9

Martin Loyen, Thorsten Wiech, Stefan Reuter, Gerold Thölking

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引用次数: 0

Abstract

Background: Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections.

Case presentation: We herein present the case of a 62-year-old male patient who presented with fatigue and was found to have severe anemia, impaired renal function, and nephrotic syndrome. A renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) of the immune complex type with activation of the classical complement pathway. Further investigations led to the diagnosis of a chronic Coxiella burnetii-infection (Q fever), likely acquired during cycling trips in a region known for intensive sheep farming. Additionally, the patient was found to have a post endocarditic destructive bicuspid aortic valve caused by this pathogen. Treatment with hydroxychloroquine and doxycycline was administered for a duration of 24 months. The aortic valve was replaced successfully and the patient recovered completely.

Conclusions: Early detection and targeted treatment of this life-threatening disease is crucial for complete recovery of the patient.

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病例报告：与 Q 热相关的膜增生性肾小球肾炎导致慢性心内膜炎。

背景：膜增生性肾小球肾炎是一种罕见的疾病：膜增生性肾小球肾炎是一种罕见的疾病，可由自身免疫性疾病、各种药物和感染引起：我们在此介绍一名 62 岁男性患者的病例，他因疲劳而就诊，被发现患有严重贫血、肾功能受损和肾病综合征。肾活检显示他患有免疫复合物型膜增生性肾小球肾炎（MPGN），经典补体途径被激活。进一步检查发现，患者被诊断为慢性烧伤性柯克西氏菌感染（Q 热），很可能是在一个以集约化养羊而闻名的地区骑自行车旅行时感染的。此外，患者还被发现患有由这种病原体引起的心内膜炎后破坏性双尖主动脉瓣。患者接受了长达 24 个月的羟氯喹和多西环素治疗。主动脉瓣置换成功，患者完全康复：结论：早期发现并有针对性地治疗这种危及生命的疾病对患者的完全康复至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Nephrology UROLOGY & NEPHROLOGY-

CiteScore

4.30

自引率

0.00%

发文量

375

审稿时长

3-8 weeks

期刊介绍： BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.