Dissecting the roles of exosomal cancer-associated fibroblasts-derived non-coding RNAs in tumor progression: A complete guide

IF 2.9 4区 医学 Q2 PATHOLOGY
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引用次数: 0

Abstract

Cancer-associated fibroblasts are the most important cellular component of the tumor microenvironment, controlling cancer progression and therapeutic response. These cells in the tumor microenvironment regulate tumor progression and development as oncogenic or tumor suppressor agents. However, the mechanisms by which CAFs communicate with cancer cells remain to investigate. Here, we review evidence that extracellular vesicles, particularly exosomes, serve as vehicles for the intercellular transfer of bioactive cargos, notably microRNAs and long non-coding RNAs, from CAFs to cancer cells. We try to highlight molecular pathways of non-coding RNAs and the interaction among these molecules. Together, these findings elucidate a critical exosome-based communication axis by which CAFs create mostly a supportive pro-tumorigenic microenvironment and highlight therapeutic opportunities for disrupting this intercellular crosstalk.

剖析外泌体癌症相关成纤维细胞衍生的非编码 RNA 在肿瘤进展中的作用:完整指南
癌症相关成纤维细胞是肿瘤微环境中最重要的细胞成分,控制着癌症的进展和治疗反应。肿瘤微环境中的这些细胞作为致癌因子或肿瘤抑制因子调节肿瘤的进展和发展。然而,CAFs 与癌细胞沟通的机制仍有待研究。在这里,我们回顾了细胞外囊泡,尤其是外泌体,作为细胞间生物活性载体,特别是微RNA和长非编码RNA从CAFs向癌细胞转移的证据。我们试图强调非编码 RNA 的分子途径以及这些分子之间的相互作用。这些发现共同阐明了一个关键的基于外泌体的通讯轴,CAFs 通过这个轴创造了一个支持性的促肿瘤微环境,并突出了破坏这种细胞间串扰的治疗机会。
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来源期刊
CiteScore
5.00
自引率
3.60%
发文量
405
审稿时长
24 days
期刊介绍: Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
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