Vestibular prepulse inhibition of the human blink reflex

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-08-14 DOI:10.1016/j.clinph.2024.08.008

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引用次数: 0

Abstract

Objective

Auditory and somatosensory prepulses are commonly used to assess prepulse inhibition (PPI). The effect of a vestibular prepulse upon blink reflex excitability has not been hitherto assessed.

Methods

Twenty-two healthy subjects and two patients with bilateral peripheral vestibular failure took part in the study. Whole body yaw rotation in the dark provided a vestibular inertial prepulse. Blink reflex was electrically evoked after the end of the rotation. The amplitude of R1 and the area-under-the-curve (area) of the blink reflex R2 and R2c responses were recorded and analysed.

Results

A vestibular prepulse inhibited the R2 (p < 0.001) and R2c area (p < 0.05). Increasing the angular acceleration did not increase the R2 and R2c inhibition (p > 0.05). Voluntary suppression of the vestibulo-ocular reflex did not affect the magnitude of inhibition (p > 0.05). Patients with peripheral vestibular failure did not show any inhibition.

Conclusions

Our data support a vestibular gating mechanism in humans.

Significance

The main brainstem nucleus mediating PPI – the pedunculopontine nucleus (PPN) – is heavily vestibular responsive, which is consistent with our findings of a vestibular-mediated PPI. Our technique may be used to interrogate the fidelity of brain circuits mediating vestibular-related PPN functions. Given the PPN’s importance in human postural control, our technique may also provide a neurophysiological biomarker of balance.

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前庭对人类眨眼反射的前脉冲抑制

目的听觉和躯体感觉前脉冲通常用于评估前脉冲抑制（PPI）。方法22名健康受试者和两名双侧外周前庭功能衰竭患者参加了这项研究。黑暗中的全身偏航旋转提供了前庭惯性预脉冲。旋转结束后，电诱发眨眼反射。结果前庭预脉冲抑制了 R2（p < 0.001）和 R2c 面积（p < 0.05）。增加角加速度不会增加 R2 和 R2c 抑制（p >；0.05）。前庭眼反射的自愿抑制并不影响抑制的程度（p > 0.05）。结论我们的数据支持人类的前庭门控机制。意义介导PPI的主要脑干核团--足突核团（PPN）--具有很强的前庭反应性，这与我们发现的前庭介导的PPI是一致的。我们的技术可用于检查介导前庭相关 PPN 功能的大脑回路的保真度。鉴于 PPN 在人类姿势控制中的重要性，我们的技术还可以提供平衡的神经生理学生物标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.

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