The Role of Natural Low Molecular Weight Dicarbonyls in Atherogenesis and Diabetogenesis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-20 eCollection Date: 2024-08-01 DOI:10.31083/j.rcm2508295

Vadim Z Lankin, Alla K Tikhaze, Mars G Sharapov, Galina G Konovalova

引用次数: 0

Abstract

This review summarises the data from long-term experimental studies and literature data on the role of oxidatively modified low-density lipoproteins (LDL) in atherogenesis and diabetogenesis. It was shown that not "oxidized" (lipoperoxide-containing) LDL, but dicarbonyl-modified LDL are atherogenic (actively captured by cultured macrophages with the help of scavenger receptors), and also cause expression of lectin like oxidized low density lipoprotein receptor 1 (LOX-1) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 1 (NOX-1) genes in endotheliocytes, which stimulate apoptosis and endothelial dysfunction. The obtained data allowed us to justify new approaches to pharmacotherapy of atherosclerosis and diabetes mellitus.

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天然低分子量二羰基在动脉粥样硬化和糖尿病发生中的作用

本综述总结了关于氧化修饰的低密度脂蛋白（LDL）在动脉粥样硬化和糖尿病发生中的作用的长期实验研究数据和文献数据。研究表明，不是 "氧化"（含过氧化脂质）的低密度脂蛋白，而是二羰基修饰的低密度脂蛋白会导致动脉粥样硬化（在清道夫受体的帮助下被培养的巨噬细胞主动捕获）、而且还会导致内皮细胞中氧化低密度脂蛋白受体 1（LOX-1）和烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶 1（NOX-1）等凝集素基因的表达，从而刺激细胞凋亡和内皮功能障碍。获得的数据使我们能够证明动脉粥样硬化和糖尿病药物治疗的新方法是正确的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.