MRI Indices of Glymphatic Function Correlate With Disease Duration in Idiopathic Intracranial Hypertension.

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Marc A Bouffard, Mahsa Alborzi Avanaki, Jeremy N Ford, Narjes Jaafar, Alexander Brook, Bardia Abbasi, Nurhan Torun, David Alsop, Donnella S Comeau, Yu-Ming Chang
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引用次数: 0

Abstract

Background: The glymphatic system represents an extravascular network of astrocytic channels responsible for interstitial fluid and solute transit through the brain parenchyma. Its dysfunction has been considered as a possible cause of idiopathic intracranial hypertension (IIH).

Methods: We enrolled participants with active IIH, treated or cured IIH, and controls. The active IIH group was divided into untreated participants with recently developed (<6 mo) and chronic (6+ mo) disease. Glymphatic function was assessed using diffusion tensor imaging along the paravascular space (DTI-ALPS) to generate an ALPS-index, hypothesized to measure glymphatic function. Participants were imaged before lumbar puncture (LP) if IIH was suspected and following LP when possible.

Results: ALPS indices were higher in participants with chronically present, active IIH than in those either with recently developed IIH or control participants. ALPS-indices correlated with papilledema but did not correlate significantly with age, BMI, or intracranial pressure (ICP).

Conclusions: Our findings suggest that DTI-ALPS-indices of glymphatic function may be influenced by the chronicity of intracranial hypertension but do not support the hypothesis that glymphatic dysfunction causes IIH. Though these findings are preliminary, glymphatic imaging may be a useful radiographic biomarker in IIH.

特发性颅内高压症患者脑腺功能的核磁共振成像指标与病程有关
背景:甘油系统是一个由星形胶质细胞通道组成的血管外网络,负责间质液体和溶质在脑实质内的转运。它的功能障碍被认为是特发性颅内高压(IIH)的一个可能原因:我们招募了活动性特发性颅内高压患者、接受治疗或治愈的特发性颅内高压患者以及对照组。活动性 IIH 组分为未经治疗的患者和新近发病的患者:长期存在的活动性 IIH 患者的 ALPS 指数高于近期发病的 IIH 患者或对照组患者。ALPS指数与乳头水肿相关,但与年龄、体重指数或颅内压(ICP)无明显相关性:我们的研究结果表明,糖膜功能的 DTI-ALPS 指数可能会受到颅内高压慢性化的影响,但并不支持糖膜功能障碍导致 IIH 的假设。虽然这些研究结果还只是初步的,但肾上腺成像可能是 IIH 的一种有用的放射生物标志物。
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来源期刊
Journal of Neuro-Ophthalmology
Journal of Neuro-Ophthalmology 医学-临床神经学
CiteScore
2.80
自引率
13.80%
发文量
593
审稿时长
6-12 weeks
期刊介绍: The Journal of Neuro-Ophthalmology (JNO) is the official journal of the North American Neuro-Ophthalmology Society (NANOS). It is a quarterly, peer-reviewed journal that publishes original and commissioned articles related to neuro-ophthalmology.
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