Psychopathology in Infants, Toddlers, and Preschool Children with Nonsyndromic Clefts of the Lip and/or Palate: A Case-Control Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-03 DOI:10.1097/SCS.0000000000010559

Semih Baghaki, Gul Karacetin, Elif Yerlikaya Oral, Ayse Beste Guzel Tuncer, Turkay Demir, Hulya Bingol Caglayan, Omer Uysal, Ozlem Ozdamar Mandi

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Abstract

Objective: The aim of this study is to assess psychopathology and maternal interactions in infants, toddlers, and preschool children with nonsyndromic clefts of the lip and/or palate (NSCLP) and association of psychopathology with cleft-related factors and maternal interactions.

Design: Twenty-six children from 4 to 72 months of age with NSCLP, who were attending the Plastic, Reconstructive and Aesthetic Surgery Department were included as the case group. Fifty-two healthy children who were matched on age and sex with the case group were taken as controls. Children were assessed in aspects of psychiatric diagnosis, articulation, and development.

Results: Speech and language disorders (SLD) ( P <0.001), disorders of affect (DA) ( P =0.005), feeding behavior disorder ( P =0.002), sleep-behavior disorder (SBD) ( P =0.038), and disordered mother-child relationship ( P <0.001) were more prevalent in children with NSCLP. Dental alignment ( P =0.024), number of operations ( P =0.006), and type of operations ( P =0.012) were associated with DA. The children in the case group, who had disordered relationship with their mothers had significantly more SLD ( P =0.036) and SBD ( P =0.039).

Conclusions: Children with NSCLP are at risk of developing psychopathology, especially SLD and DA. Maternal interactions and the above cleft-related factors and may be the target of interventions to prevent and treat psychiatric disorders in these children.

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患有非综合征唇腭裂的婴儿、幼儿和学龄前儿童的心理病理学：病例对照研究

研究目的本研究旨在评估患有非综合征性唇腭裂（NSCLP）的婴儿、幼儿和学龄前儿童的心理病理学和母亲互动情况，以及心理病理学与唇裂相关因素和母亲互动的关联：设计：26 名 4 至 72 个月大的 NSCLP 患儿被纳入病例组，他们在整形、修复和美容外科就诊。52名在年龄和性别上与病例组相符的健康儿童作为对照组。对儿童进行精神诊断、发音和发育方面的评估：结果：言语和语言障碍（SLD）（PC结论：患有 NSCLP 的儿童有发展成精神病态的风险，尤其是 SLD 和 DA。母婴互动和上述与裂隙有关的因素可能是预防和治疗这些儿童精神障碍的干预目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.