Multifaceted paternal exposures before conception and their epigenetic impact on offspring.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2024-09-04 DOI:10.1007/s10815-024-03243-1

Xiaojing Wu, Weiping Zhang, Huijun Chen, Jianfei Weng

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Abstract

As scientific research progresses, there is an increasing understanding of the importance of paternal epigenetics in influencing the health and developmental path of offspring. Prior to conception, the environmental exposures and lifestyle choices of fathers can significantly influence the epigenetic state of sperm, including DNA methylation and histone changes, among other factors. These alterations in epigenetic patterns have the potential for transgenerational transmission potential and may exert profound effects on the biological characteristics of descendants. Paternal epigenetic changes not only affect the regulation of gene expression patterns in offspring but also increase the risk to certain diseases. It is crucial to comprehend the conditions that fathers are exposed to before conception and the potential outcomes of these conditions. This understanding is essential for assessing personal reproductive decisions and anticipating health risks for future generations. This review article systematically summarizes and analyzes current research findings regarding how paternal pre-pregnancy exposures influence offspring as well as elucidates underlying mechanisms, aiming to provide a comprehensive perspective for an enhanced understanding of the impact that paternal factors have on offspring health.

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父亲在受孕前的多方面暴露及其对后代的表观遗传影响。

随着科学研究的进展，人们越来越认识到父亲的表观遗传学在影响后代健康和发育道路方面的重要性。在受孕前，父亲接触的环境和选择的生活方式会极大地影响精子的表观遗传状态，包括 DNA 甲基化和组蛋白变化等因素。这些表观遗传模式的改变具有跨代传递的潜力，并可能对后代的生物特征产生深远影响。父系表观遗传变化不仅会影响后代基因表达模式的调控，还会增加罹患某些疾病的风险。了解父亲在受孕前所接触到的条件以及这些条件的潜在结果至关重要。这种了解对于评估个人生育决定和预测后代的健康风险至关重要。这篇综述文章系统地总结和分析了目前有关父亲孕前暴露如何影响后代的研究成果，并阐明了其背后的机制，旨在提供一个全面的视角，加深对父亲因素对后代健康影响的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.