Exploring real-world prescribing patterns for maintenance treatment in bipolar disorders: a focus on antidepressants and benzodiazepines.

IF 2.9 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2024-09-04 DOI:10.1080/13651501.2024.2398796

Sanja Andric Petrovic, Dusan Jankovic, Nina Kaurin, Vanja Mandic Maravic, Danilo Pesic, Ivan Ristic, Nadja P Maric

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引用次数: 0

Abstract

Objective: Bipolar disorders (BD) are characterized by highly recurrent nature, necessitating adequate maintenance treatment for long-term disorder control. This study aimed to investigate real-world prescribing patterns among outpatients with BD, focusing on the utilisation of antidepressants (AD) and benzodiazepines (BDZ).

Methods: We analysed prescription patterns of the five main groups of psychotropic medications (antipsychotics, mood stabilizers, AD, BDZ, and anticholinergic medications) and their relationships with basic socio-demographic and clinical data in a sample of 107 clinically stable BD outpatients (75.7% female, age 44.8 ± 11.7).

Results: Maintenance therapy predominantly involved polypharmacy (92.5%), with mood stabilizers (87.9%) and antipsychotics (80.4%, predominantly second-generation) being the most commonly prescribed. Our findings highlight a high percentage of patients prescribed AD (50.5%) and BDZ (54.2%). BDZ patients, compared to the non-BDZ group in maintenance treatment, were significantly older with longer psychiatric history and a decreased likelihood of comorbid personality disorder diagnoses.

Conclusions: This study offers insights into prescribing practices within a university psychiatric clinic in the Western Balkans. The prevalent use of polypharmacy in real-world clinical settings, along with high percentage of patients prescribed AD and BDZ, suggests a gap between guideline recommendations and clinical practice, indicating a lack of consensus or standardized approaches in clinical practice.

查看原文本刊更多论文

探索现实世界中双相情感障碍维持治疗的处方模式：关注抗抑郁药和苯二氮卓类药物。

目的：双相情感障碍（BD）具有高度复发性的特点，需要适当的维持治疗才能长期控制病情。本研究旨在调查躁郁症门诊患者的实际处方模式，重点关注抗抑郁药（AD）和苯二氮卓类药物（BDZ）的使用情况：我们以 107 名临床稳定的 BD 门诊患者（75.7% 为女性，年龄为 44.8 ± 11.7）为样本，分析了五大类精神药物（抗精神病药、情绪稳定剂、抗抑郁药、苯二氮卓类药物和抗胆碱能药物）的处方模式及其与基本社会人口学和临床数据的关系：维持治疗主要涉及多种药物（92.5%），其中情绪稳定剂（87.9%）和抗精神病药（80.4%，主要是第二代）是最常用的处方药。我们的研究结果表明，开具 AD（50.5%）和 BDZ（54.2%）处方的患者比例较高。与接受维持治疗的非 BDZ 组患者相比，BDZ 组患者的年龄明显较大，精神病史较长，合并人格障碍诊断的可能性较低：本研究有助于深入了解西巴尔干地区一所大学精神病诊所的处方做法。在现实世界的临床环境中普遍使用多种药物，而且开具 AD 和 BDZ 处方的患者比例很高，这表明指南建议与临床实践之间存在差距，表明临床实践中缺乏共识或标准化方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.