Impact of complete versus culprit-only revascularization on major adverse cardiovascular event in diverse subpopulations.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2024-09-04 DOI:10.1080/14796678.2024.2387516

Huzaifa Ul Haq Ansari, Farea Noman Dar, Narmeen Shaikh, Ayesha Noman, Kamran Ahmed, Uzair Asad, Khansa Khalid, Moiz Ahmed, Ahmad Zakarya, Usman Leel, Ruhina Adil Shaikh, Kiran Abbas

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Abstract

Background: Myocardial infarction management relies on pharmaceuticals and interventions like percutaneous coronary intervention (PCI). While complete PCI has shown noninferiority to culprit-only PCI, its impact on major adverse cardiovascular events (MACE) outcomes in multiple subpopulations has been unknown.Methods: A systematic literature search (from January 2000 to May 2024) identified four relevant randomized controlled trials involving ST-segment elevation myocardial infarction patients. Data analysis employed a random-effects model with inverse variance weighting.Results: MACE risk was significantly lower in males than females undergoing complete PCI compared with culprit-only PCI (hazard ratio: 0.52; 95% CI: 0.39-0.68; p < 0.01; I2 = 53%). Furthermore, complete PCI significantly lowered the risk of MACE outcomes in patients without diabetes and in patients under the 65-year age limit in comparison to culprit-only PCI.Conclusion: Complete PCI reduces MACE risk in male, nondiabetic ST-segment elevation myocardial infarction patients under 65 with multivessel coronary artery disease, necessitating further investigation into outcome differences among different subpopulations.

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在不同亚人群中，完全血运重建与单纯罪魁祸首血运重建对主要不良心血管事件的影响。

背景：心肌梗死的治疗依赖于药物和经皮冠状动脉介入治疗（PCI）等干预措施。虽然完全 PCI 显示出非劣于单纯罪魁祸首 PCI，但其对多个亚人群的主要不良心血管事件（MACE）结果的影响尚不清楚：系统性文献检索（2000 年 1 月至 2024 年 5 月）确定了四项涉及 ST 段抬高型心肌梗死患者的相关随机对照试验。数据分析采用了反方差加权随机效应模型：结果：与单纯罪魁祸首PCI相比，男性接受完全PCI的MACE风险明显低于女性（危险比：0.52；95% CI：0.39-0.68；P 结论：完全PCI降低了男性心肌梗死患者的MACE风险：完全PCI可降低65岁以下男性非糖尿病ST段抬高型心肌梗死患者多支血管冠状动脉疾病的MACE风险，因此有必要进一步研究不同亚人群之间的结果差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.

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