Transcription of biological aging markers (ANRIL, P16^INK4a, TBX2, and TERRA) and their correlations with severity of sulfur mustard exposure in veterans.

IF 2.1 4区医学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Drug and Chemical Toxicology Pub Date : 2024-09-03 DOI:10.1080/01480545.2024.2395571

Leila Nasiri, Mohammad-Reza Vaez-Mahdavi, Hossein Hassanpour, Tooba Ghazanfari, Sussan Kaboudanian Ardestani, Nayere Askari, Sara Ghaffarpour, Mohammad Saber Zamani

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Abstract

Sulfur mustard (SM) exposure has delayed harmful effects, including premature biological aging. This study aimed to evaluate the expression of aging markers (i.e., ANRIL, P16^INK4a, TBX2, and TERRA) and assess their correlation with the severity of SM exposure in the long term. The study was conducted on two volunteer groups. 1) SM-exposed group, exposed to SM once in 1987 during the war; divided into three subgroups based on the injury severity, asymptomatic (without any clinical signs), mild, and severe; 2) Non-exposed group. In the SM-exposed group, ANRIL transcript was decreased, especially in subgroups of mild and severe. TBX2 transcript was also decreased in the total SM-exposed group. This decrease was more significant in the mild and severe subgroups than in asymptomatic ones. P16^INK4a transcript was increased in the SM-exposed group, especially in the asymptomatic subgroup. The increase in TERRA transcript was also significant in all subgroups. There was a positive correlation between the TERRA transcript and the severity of injury, while this correlation was negative for the ANRIL. It is concluded that the delayed toxicity of SM may be associated with dysregulation of aging markers leading to premature cellular aging. These markers' alterations differed according to the severity of SM injury.

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退伍军人生物衰老标志物（ANRIL、P16INK4a、TBX2 和 TERRA）的转录及其与硫芥子气暴露严重程度的相关性。

接触硫芥子气（SM）会产生延迟性有害影响，包括生物提前衰老。本研究旨在评估衰老标志物（即 ANRIL、P16INK4a、TBX2 和 TERRA）的表达，并评估它们与长期接触 SM 的严重程度的相关性。研究在两组志愿者身上进行。1) SM 暴露组，1987 年战争期间暴露于一次 SM；根据损伤严重程度分为三个亚组，无症状组（无任何临床症状）、轻度组和重度组；2) 非暴露组。在接触过 SM 的组中，ANRIL 转录本减少，尤其是在轻度和重度亚组中。在所有暴露于 SM 的组别中，TBX2 转录本也有所下降。与无症状亚组相比，轻度和重度亚组的这种降低更为明显。P16INK4a转录本在SM暴露组中增加，尤其是在无症状亚组中。在所有亚组中，TERRA 转录本也显著增加。TERRA 转录本与损伤的严重程度呈正相关，而 ANRIL 则呈负相关。结论是，SM 的延迟毒性可能与导致细胞过早衰老的衰老标志物失调有关。这些标志物的改变因 SM 损伤的严重程度而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug and Chemical Toxicology 医学-毒理学

CiteScore

6.00

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Drug and Chemical Toxicology publishes full-length research papers, review articles and short communications that encompass a broad spectrum of toxicological data surrounding risk assessment and harmful exposure. Manuscripts are considered according to their relevance to the journal. Topics include both descriptive and mechanics research that illustrates the risk assessment implications of exposure to toxic agents. Examples of suitable topics include toxicological studies, which are structural examinations on the effects of dose, metabolism, and statistical or mechanism-based approaches to risk assessment. New findings and methods, along with safety evaluations, are also acceptable. Special issues may be reserved to publish symposium summaries, reviews in toxicology, and overviews of the practical interpretation and application of toxicological data.