Nerve sonography to detect intraneural microvascularity in patients with peripheral neuropathy

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-08-24 DOI:10.1016/j.clinph.2024.08.011

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引用次数: 0

Abstract

Objective

We assessed microvessel flow within peripheral nerves using nerve sonography in patients with peripheral neuropathy.

Methods

This study included consecutive patients with peripheral neuropathy who were admitted to our hospital. The patients were divided into two groups: inflammatory neuropathies for immune-mediated neuropathies, such as Guillain − Barré syndrome and chronic inflammatory demyelinating polyneuropathy, and the rest were defined as non-inflammatory neuropathies. We assessed nerve size and intraneural blood flow at four sites on each median and ulnar nerve. Blood flow was evaluated using color Doppler imaging, advanced dynamic flow (ADF), and superb microvascular imaging (SMI) techniques.

Results

Thirty-nine patients (median age, 60.0 years; 20 male) were enrolled in this study. An increase in intraneural blood flow was observed in five patients when evaluated by color Doppler, five patients by ADF, and 13 patients by SMI. An overall analysis of the three methods showed that intraneural blood flow was significantly higher in patients with inflammatory neuropathy than in those with non-inflammatory neuropathy (54.2% vs. 0%, p = 0.0005).

Conclusions

Intraneural hypervascularization is more frequent in patients with inflammatory neuropathy than in those with non-inflammatory neuropathy.

Significance

Evaluation of microvessel flow within peripheral nerves may contribute to the diagnosis of peripheral neuropathy.

查看原文本刊更多论文

通过神经超声波检测周围神经病变患者的神经内微血管。

目的通过神经超声波检查评估周围神经病变患者周围神经内的微血管流量：研究对象包括本院收治的连续性周围神经病患者。这些患者被分为两组：炎症性神经病变为免疫介导的神经病变，如吉兰-巴雷综合征和慢性炎症性脱髓鞘性多发性神经病变；其余患者被定义为非炎症性神经病变。我们分别在正中神经和尺神经的四个部位评估了神经大小和神经内血流。我们使用彩色多普勒成像、高级动态血流（ADF）和超微血管成像（SMI）技术对血流进行了评估：39 名患者（中位年龄 60.0 岁；20 名男性）参加了这项研究。在使用彩色多普勒、ADF 和 SMI 分别对 5 名患者、5 名患者和 13 名患者进行评估时，均观察到硬膜内血流增加。对三种方法的总体分析表明，炎症性神经病变患者的硬膜内血流明显高于非炎症性神经病变患者（54.2% 对 0%，P = 0.0005）：结论：与非炎症性神经病变患者相比，炎症性神经病变患者的硬膜内血管过多更为常见：对周围神经内微血管流动的评估可能有助于周围神经病变的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.