Efficacy and safety of PARPis combined with an ICIs for advanced or metastatic triple-negative breast cancer: a single-arm meta-analysis.

IF 4.2 3区 医学 Q2 ONCOLOGY
Qiao Zheng, Tiecheng Zhou, Weijun Ding
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Abstract

Although the intervention for triple-negative breast cancer (TNBC) patients has improved and survival time has increased, the combination of immune checkpoint inhibitors(ICIs) and PARP inhibitors (Poly ADP-Ribose Polymerase inhibitors, PARPis) is still controversial. Previous studies revealed that the combined use of ICIs and PARPis led to increased antitumor activity. However, most of these combined regimens are nonrandomized controlled trials with small sample sizes. The purpose of this meta-analysis was to evaluate the efficacy and safety of ICIs combined with PARPis in patients with advanced or metastatic TNBC. The PubMed, Embase, Cochrane Library and Web of Science databases were systematically searched. The results including the objective remission rate (ORR), disease control rate (DCR), progression-free survival (PFS) and adverse events (AEs), were subjected to further analysis. Four studies involving 110 subjects were included in this meta-analysis. The combined ORR and DCR were 23.6% and 53.6%, respectively; while the ORR and DCR of BRCAmut patients were 38.1% and 71.4%, respectively. The median PFS of the patients was 4.29 months. As for safety, the most common AEs were nausea (49.0%), anemia (44.3%) and fatigue (40.6%). Most of them were grade 1 or 2, and the incidence of adverse events ≥ III was obviously low. Except for anemia, the incidence of AEs ≥ III was < 10%. This meta-analysis revealed that the combination of ICIs and PARPis has good efficacy and safety for advanced or metastatic TNBC patients.

Abstract Image

PARPis 联合 ICIs 治疗晚期或转移性三阴性乳腺癌的有效性和安全性:单臂荟萃分析。
尽管对三阴性乳腺癌(TNBC)患者的干预有所改善,生存时间也有所延长,但免疫检查点抑制剂(ICIs)和PARP抑制剂(Poly ADP-Ribose Polymerase inhibitors,PARPis)的联合使用仍存在争议。以往的研究表明,联合使用 ICIs 和 PARPis 可提高抗肿瘤活性。然而,这些联合治疗方案大多是样本量较小的非随机对照试验。本荟萃分析旨在评估 ICIs 与 PARPis 联用对晚期或转移性 TNBC 患者的疗效和安全性。我们系统地检索了 PubMed、Embase、Cochrane Library 和 Web of Science 数据库。结果包括客观缓解率(ORR)、疾病控制率(DCR)、无进展生存期(PFS)和不良事件(AEs),并对这些结果进行了进一步分析。本次荟萃分析共纳入了四项研究,涉及 110 名受试者。合并 ORR 和 DCR 分别为 23.6% 和 53.6%;而 BRCAmut 患者的 ORR 和 DCR 分别为 38.1% 和 71.4%。患者的中位生存期为4.29个月。在安全性方面,最常见的不良反应是恶心(49.0%)、贫血(44.3%)和疲劳(40.6%)。这些不良反应大多为 1 级或 2 级,≥ III 级的不良反应发生率明显较低。除贫血外,不良反应发生率≥ III 级的有
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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