Exosomes That Have Different Cellular Origins Followed by the Impact They Have on Prostate Tumor Development in the Tumor Microenvironment

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-04 DOI:10.1002/cnr2.70001

Cong Huang, Jialong Zhang, Hongzhi Wang, Chaozhao Liang

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Abstract

Background

Prostate cancer (PCa) is the most common urinary tumor with the highest incidence rate and the second among the leading causes of death worldwide for adult males. In the worldwide cancer incidence rate, PCa is on the increase. The cancerous cells in the prostate and cells in the microenvironment surrounding the tumor communicate through signal transduction, which is crucial for the development and spread of PCa.

Recent findings

Exosomes are nanoscale vesicles released into body fluids by various cells that can aid intercellular communication by releasing nucleic acids and proteins. Exosomes published by different types of cells in the tumor microenvironment can have varying impacts on the proliferation and growth of tumor cells via various signaling pathways, modes of action, and secreted cytokines.

Conclusion

The main purpose of this review is to describe the effects of different cell-derived exosomes in the tumor microenvironment of PCa on the progression of tumor cells, as well as to summarize and discuss the prospects for the application of exosomes in the treatment and diagnosis of PCa.

Abstract Image

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具有不同细胞起源的外泌体及其对肿瘤微环境中前列腺肿瘤发展的影响。

背景：前列腺癌（PCa）是最常见的泌尿系统肿瘤，发病率最高，也是全球成年男性的第二大死因。在全球癌症发病率中，前列腺癌呈上升趋势。前列腺中的癌细胞与肿瘤周围微环境中的细胞通过信号转导进行交流，这对 PCa 的发展和扩散至关重要：外泌体是各种细胞释放到体液中的纳米级囊泡，可通过释放核酸和蛋白质帮助细胞间的交流。肿瘤微环境中不同类型细胞释放的外泌体可通过不同的信号通路、作用方式和分泌的细胞因子对肿瘤细胞的增殖和生长产生不同的影响：本综述的主要目的是描述 PCa 肿瘤微环境中不同细胞衍生的外泌体对肿瘤细胞进展的影响，并总结和探讨外泌体在 PCa 治疗和诊断中的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.