Ultrasound Probe Pressure Affects Aortic Wall Stiffness: A Patient-Specific Computational Study in Abdominal Aortic Aneurysms.

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL
Marta Irene Bracco, Ali Akbar Karkhaneh Yousefi, Laurence Rouet, Stéphane Avril
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Abstract

Purpose: Ultrasound imaging is key in the management of patients with an abdominal aortic aneurysm (AAA). It was recently shown that the cyclic diameter variations between diastole and systole, which can be quantified with US imaging, increase significantly with the strength of the applied probe pressure on the patient's abdomen. The goal of this study is to investigate this effect more thoroughly.

Methods: With finite-element modeling, pulsatile blood pressure and probe pressure are simulated in three patient-specific geometries. Two distinct models for the aortic wall were simulated: a nonlinear hyperelastic and a linear elastic model. In addition, varying stiffness was considered for the surrounding tissues. The effect of light, moderate, and firm probe pressure was quantified on the stresses and strains in the aortic wall, and on two in vivo stiffness measures. In addition, the Elasticity Loss Index was proposed to quantify the change in stiffness due to probe pressure.

Results: Firm probe pressure decreased the measured aortic stiffness, and material stiffness was affected only when the wall was modeled as nonlinear, suggesting a shift in the stress-strain curve. In addition, stiffer surrounding tissues and a more elongated aneurysm sac decreased the responsiveness to the probe pressure.

Conclusion: The effect of probe pressure on the AAA wall stiffness was clarified. In particular, the AAA wall nonlinear behavior was found to be of primary importance in determining the probe pressure response. Thus, further work will intend to make use of this novel finding in a clinical context.

Abstract Image

超声探头压力影响主动脉壁硬度:针对腹主动脉瘤患者的计算研究。
目的:超声成像是治疗腹主动脉瘤(AAA)患者的关键。最近的研究表明,可通过超声成像量化的舒张期和收缩期之间的周期性直径变化会随着患者腹部探头压力的增加而显著增加。本研究的目的是更深入地研究这一影响:方法:通过有限元建模,模拟了三种患者特定几何形状下的搏动血压和探头压力。模拟了主动脉壁的两种不同模型:非线性超弹性模型和线性弹性模型。此外,还考虑了周围组织的不同硬度。对轻度、中度和重度探针压力对主动脉壁应力和应变的影响,以及对两种体内硬度测量值的影响进行了量化。此外,还提出了弹性损失指数来量化探针压力导致的硬度变化:结果:坚硬的探针压力降低了测得的主动脉刚度,只有当主动脉壁被模拟为非线性时,材料刚度才会受到影响,这表明应力-应变曲线发生了变化。此外,较硬的周围组织和较长的动脉瘤囊也降低了对探针压力的响应速度:结论:探头压力对 AAA 壁僵硬度的影响已得到明确。结论:探头压力对动脉瘤壁刚度的影响得到了澄清,尤其是发现动脉瘤壁的非线性行为在决定探头压力响应方面起着至关重要的作用。因此,进一步的工作将是把这一新发现应用于临床。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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