An ultrathin organic–inorganic integrated device for optical biomarker monitoring

IF 33.7 1区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

Nature Electronics Pub Date : 2024-09-03 DOI:10.1038/s41928-024-01237-6

Kyung Yeun Kim, Joohyuk Kang, Sangmin Song, Kyungwoo Lee, Suk-Won Hwang, Seung Hwan Ko, Hojeong Jeon, Jae-Hoon Han, Wonryung Lee

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引用次数: 0

Abstract

Organic electrochemical transistors can be used in wearable sensors to amplify biological signals. Other wireless communication systems are required for applications in continuous health monitoring. However, conventional wireless communication circuits, which are based on inorganic integrated chips, face limitations in terms of conformability due to the thick and rigid integrated circuit chips. Here, we report an ultrathin organic–inorganic device for wireless optical monitoring of biomarkers, such as glucose in sweat and glucose, lactate and pH in phosphate-buffered saline. The conformable system integrates an organic electrochemical transistor and a near-infrared inorganic micro-light-emitting diode on a thin parylene substrate. The device has an overall thickness of 4 μm. The channel current of the transistor changes according to the biomarker concentration, which alters the irradiance from the light-emitting diode to enable biomarker monitoring. We combine the device with an elastomeric battery circuit to create a wearable patch. We also show that the system can be used for near-infrared image analysis. A wireless monitoring system that integrates an organic electrochemical transistor and a near-infrared inorganic micro-light-emitting diode on a thin parylene substrate can be used to monitor biomarkers such as glucose, lactate and pH.

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用于光学生物标记监测的超薄有机-无机集成装置

有机电化学晶体管可用于可穿戴式传感器，以放大生物信号。持续健康监测应用还需要其他无线通信系统。然而，传统的无线通信电路以无机集成芯片为基础，由于集成电路芯片又厚又硬，在适配性方面受到限制。在此，我们报告了一种超薄有机无机设备，用于无线光学监测生物标志物，如汗液中的葡萄糖和磷酸盐缓冲盐水中的葡萄糖、乳酸盐和 pH 值。这种可适配系统将一个有机电化学晶体管和一个近红外无机微发光二极管集成在一个薄的对二甲苯衬底上。该器件的整体厚度为 4 微米。晶体管的沟道电流随生物标记物浓度的变化而变化，从而改变发光二极管的辐照度，实现生物标记物监测。我们将该装置与弹性电池电路相结合，创造出一种可穿戴的贴片。我们还展示了该系统可用于近红外图像分析。

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来源期刊

Nature Electronics Engineering-Electrical and Electronic Engineering

CiteScore

47.50

自引率

2.30%

发文量

159

期刊介绍： Nature Electronics is a comprehensive journal that publishes both fundamental and applied research in the field of electronics. It encompasses a wide range of topics, including the study of new phenomena and devices, the design and construction of electronic circuits, and the practical applications of electronics. In addition, the journal explores the commercial and industrial aspects of electronics research. The primary focus of Nature Electronics is on the development of technology and its potential impact on society. The journal incorporates the contributions of scientists, engineers, and industry professionals, offering a platform for their research findings. Moreover, Nature Electronics provides insightful commentary, thorough reviews, and analysis of the key issues that shape the field, as well as the technologies that are reshaping society. Like all journals within the prestigious Nature brand, Nature Electronics upholds the highest standards of quality. It maintains a dedicated team of professional editors and follows a fair and rigorous peer-review process. The journal also ensures impeccable copy-editing and production, enabling swift publication. Additionally, Nature Electronics prides itself on its editorial independence, ensuring unbiased and impartial reporting. In summary, Nature Electronics is a leading journal that publishes cutting-edge research in electronics. With its multidisciplinary approach and commitment to excellence, the journal serves as a valuable resource for scientists, engineers, and industry professionals seeking to stay at the forefront of advancements in the field.