Functional correlation between cerebellum and basal ganglia: A parkinsonism model

L. Vásquez-Celaya , G. Marín , M.E. Hernández , P. Carrillo , C.A. Pérez , G.A. Coria-Avila , J. Manzo , M. Miquel , L.I. García
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Abstract

Introduction

The cerebellar response has been studied for years with different models of alteration of other brain structures to understand its complex functioning and its relationship with the rest of the body. Studies in patients with Parkinson's disease (PD) showed that the cerebellar function is modified by deficit of the basal ganglia; which supports the hypothesis that both structures are related anatomically and functionally.

Methods

In our study, the ventrolateral striatum (VLS) of the basal ganglia was altered by an electrolytic lesion, in order to produce a similar jaw frequency of jaw tremor movements presented in parkinsonism, thereafter we analyzed the effect of the lesion on the expression of multiunit activity (MUA) of the cerebellum.

Results

We found cerebellar activation during mandibular movements and increment during oral jaw tremor movements. In addition, the amplitude of baseline MUA registered in animals with alteration of the VLS decreased with respect to the intact group.

Conclusions

Accordingly, we conclude that cerebellar changes in MUA may be due to a decrease in the cerebellar inflectional or as a possible compensatory function between cerebellum and basal ganglia.

小脑和基底神经节之间的功能相关性:帕金森病模型
导言:多年来,人们通过改变其他大脑结构的不同模型来研究小脑反应,以了解小脑的复杂功能及其与身体其他部分的关系。对帕金森病(PD)患者的研究表明,小脑功能因基底节功能缺失而改变;这支持了这两种结构在解剖学和功能上相关的假设。方法在我们的研究中,基底节的腹外侧纹状体(VLS)被电解病变改变,以产生类似帕金森病患者下颌震颤运动的频率,之后我们分析了病变对小脑多单位活动(MUA)表达的影响。结论我们得出结论,小脑多单位活动的变化可能是由于小脑转折功能的下降或小脑与基底节之间可能存在的代偿功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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