The association between Behçet disease activity and elevated systemic immune-inflammation index: A retrospective observational study in a tertiary care hospital.

Dilek Mentesoglu, Nilgün Atakan
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Abstract

Background The systemic immune-inflammation index (SII) is a novel marker for predicting the prognosis in patients with various diseases and cancers. We aimed to investigate the relationship between SII and disease activity in patients with Behçet disease (BD). Methods Our retrospective study included 513 patients with BD aged ≥18 years. The patients were classified into an active group (n=355) and an inactive group (n=158). Pearson correlation analysis was performed to elucidate correlations between the SII and other markers. Binary logistic regression analysis was used to determine BD-related risk factors. Receiver operating characteristic (ROC) curves were computed to assess cut-offs for the predictive value of the SII and other markers. Results Patients with active BD had a significantly higher SII (p<0.001) than those in the inactive group. ROC analysis revealed that the optimal SII cut-off value to identify BD activity was 526.23, with 70.4% sensitivity and 70.3% specificity. Pearson correlation coefficient (r) demonstrated a significant positive correlation between SII, and the C-reactive protein level (r=0.427, p<0.001), erythrocyte sedimentation rate (r=0.422, p<0.001), platelet- lymphocyte ratio (r=0.711, p<0.001), and neutrophil- lymphocyte ratio (r=0.672, p<0.001). According to binary logistic regression analysis, the SII (odds ratio [OR] 1.003; 95% confidence interval [CI] 1.001-1.004; p=0.002) was an independent risk factor for active BD. Conclusion The SII can be considered a novel predictor of BD activity.

贝赫切特病活动性与全身免疫炎症指数升高之间的关联:一家三级医院的回顾性观察研究。
背景 全身免疫炎症指数(SII)是预测各种疾病和癌症患者预后的新标志物。我们旨在研究贝赫切特病(BD)患者的 SII 与疾病活动性之间的关系。方法 我们的回顾性研究包括 513 名年龄≥18 岁的白塞氏病患者。患者被分为活动组(355 人)和非活动组(158 人)。研究人员进行了皮尔逊相关分析,以阐明 SII 与其他标记物之间的相关性。二元逻辑回归分析用于确定与 BD 相关的风险因素。计算了接收者操作特征曲线(ROC),以评估 SII 和其他标记物预测价值的临界值。结果 活动性 BD 患者的 SII 明显较高(p
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