Short-Term Prognosis of Elderly Patients Admitted to the Coronary Care Unit: A Subgroup Analysis of the MORCOR-TURK (Mortality and Morbidity in Coronary Care Units in Türkiye) Trial.

Gökay Taylan, Çağlar Kaya, Mehmet Özbek, Feyza Kurt, Yücel Kaçmaz, Fatih Akkaya, Fatih Kahraman, Ahmet Seyda Yılmaz
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Abstract

Objective: This subgroup analysis of the MORCOR-TURK (Mortality and Morbidity in Coronary Care Units in Türkiye) trial aimed to determine the short-term prognosis, mortality rates, and predictors for elderly patients followed in coronary care units (CCUs) in Türkiye.

Methods: The MORCOR-TURK trial is a national, non-interventional, multicenter observational study conducted in Türkiye (ClinicalTrials.gov number NCT05296694). The study population includes CCU patients from 50 centers selected from all regions of Türkiye (between September 1 and 30, 2022 prospectively). In the subgroup analysis, patients were divided into two groups: Group 1 (ages 65 to < 75 years, n = 923 patients) and Group 2 (ages ≥ 75 years, n = 713 patients). At the end of the analysis, short-term prognosis, mortality rates, and predictors were documented.

Results: The mean age of Group 1 was 69 (67-72) years, and Group 2 was 80 (77-84) years. Chest pain was the most common reason for admission (968 patients [59.16%]), and acute coronary syndrome was the most common reason for hospitalization in the CCU (1,053 patients [64%]). Atrial fibrillation (AF) was the most common arrhythmia (356 patients [21.76%]). The mortality rate was 6.11% in elderly patients (4.23% in Group 1 and 8.56% in Group 2). The multivariate regression analysis showed that age (P = 0.046, P = 0.003), chronic kidney disease (P = 0.011, P = 0.045), and ventricular tachycardia/ventricular fibrillation (VT/VF) during hospitalization (P < 0.001) were the main factors that increased mortality in both groups. Other independent mortality risk factors were smoking for Group 1 and aortic stenosis for Group 2.

Conclusion: This study represents the most comprehensive assessment of the short-term prognosis for elderly patients admitted to CCUs in Türkiye. It showed that coronary artery disease was the most common reason for admission and age over 75 and chronic kidney disease were the main determinants of mortality.

入住冠心病监护病房的老年患者的短期预后:MORCOR-TURK(土耳其冠心病监护病房死亡率和发病率)试验分组分析》。
目的MORCOR-TURK (土耳其冠心病监护病房的死亡率和发病率)试验的亚组分析旨在确定土耳其冠心病监护病房(CCU)随访的老年患者的短期预后、死亡率和预测因素:MORCOR-TURK 试验是一项在土耳其进行的全国性、非干预性、多中心观察研究(ClinicalTrials.gov 编号 NCT05296694)。研究对象包括从土耳其所有地区选出的 50 个中心的 CCU 患者(2022 年 9 月 1 日至 30 日期间为前瞻性研究)。在亚组分析中,患者被分为两组:第 1 组(65 岁至小于 75 岁,n = 923 名患者)和第 2 组(年龄≥ 75 岁,n = 713 名患者)。分析结束后,记录了短期预后、死亡率和预测因素:第一组的平均年龄为 69(67-72)岁,第二组为 80(77-84)岁。胸痛是最常见的入院原因(968 名患者[59.16%]),急性冠状动脉综合征是在 CCU 住院的最常见原因(1053 名患者[64%])。房颤是最常见的心律失常(356 名患者 [21.76%])。老年患者的死亡率为 6.11%(第一组为 4.23%,第二组为 8.56%)。多变量回归分析显示,年龄(P = 0.046,P = 0.003)、慢性肾病(P = 0.011,P = 0.045)和住院期间室速/室颤(VT/VF)(P < 0.001)是增加两组患者死亡率的主要因素。其他独立的死亡风险因素是:第一组为吸烟,第二组为主动脉瓣狭窄:本研究是对土耳其CCU老年患者短期预后的最全面评估。研究结果表明,冠状动脉疾病是最常见的入院原因,年龄超过75岁和慢性肾病是死亡率的主要决定因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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