[Comparison of Serum Spexin Level and its Relationship with Echocardiographic Findings in Prediabetic Patients with and without Hypertension].

Sedat Taş, Ümmü Taş, Tuncay Küme
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引用次数: 0

Abstract

Objective: Prediabetes mellitus, hypertension, and their frequent coexistence are risk factors for macrovascular and cardiovascular complications. In this study we aimed to determine the relationship between spexin levels and echocardiographic findings and hypertension in prediabetic patients.

Methods: This study included 118 adult patients diagnosed with prediabetes mellitus who presented to outpatient clinics between April 2021 and January 2022. The patients were grouped into prediabetic patients with hypertension (n = 58) and those without hypertension (n = 60). The hypertension group was further divided into dipper and non-dipper groups according to the 24-hour ambulatory blood pressure monitoring. Blood samples were collected from all patients and echocardiography was performed. Spexin levels were measured by ELISA. Serum spexin levels, echocardiographic and ambulatory blood pressure monitoring findings were compared between the groups.

Results: The hypertension and non-dipper groups had significantly lower spexin levels and higher left atrial volume index, E/Em index, and interventricular septum and posterior wall thicknesses. Spexin levels were negatively correlated with body mass index (r = -0.298, P < 0.001), nighttime systolic blood pressure (r = -0.264, P = 0.006), nighttime diastolic blood pressure (r =-.255, P = 0.005), left atrial volume index (r =-.238, P = 0.009), E/Em (r =-.214,P = 0.020), and low-density lipoprotein cholesterol (r = -.243, P = 0.008). Obesity, overweight and spexin <780 pg/mL were independently associated with hypertension.

Conclusion: Circulating spexin levels were lower in prediabetic patients with overall hypertension and in non-dipper patients, and were associated with echocardiographic and lipid parameters. The cut-off value of spexin identified in our study may be a useful indicator for hypertension detection and raise clinicians' awareness about evaluating prediabetic patients for hypertension.

[有高血压和无高血压的糖尿病前期患者血清 Spexin 水平及其与超声心动图结果关系的比较]。
目的:糖尿病前期、高血压及其频繁并存是导致大血管和心血管并发症的危险因素。在这项研究中,我们旨在确定糖尿病前期患者体内 spexin 水平和超声心动图结果与高血压之间的关系:本研究纳入了 2021 年 4 月至 2022 年 1 月期间在门诊就诊的 118 名确诊为糖尿病前期的成年患者。这些患者被分为有高血压的糖尿病前期患者(58 人)和无高血压的糖尿病前期患者(60 人)。根据 24 小时动态血压监测结果,高血压组又分为低血压组和非低血压组。采集所有患者的血样并进行超声心动图检查。用酶联免疫吸附法测定矛毒素水平。比较各组之间的血清矛毒素水平、超声心动图和动态血压监测结果:结果:高血压组和非脱水组的矛毒素水平明显较低,而左心房容积指数、E/Em指数、室间隔和后壁厚度较高。Spexin水平与体重指数(r = -0.298,P < 0.001)、夜间收缩压(r = -0.264,P = 0.006)、夜间舒张压(r =-.255,P = 0.005)、左心房容积指数(r =-.238,P = 0.009)、E/Em(r =-.214,P = 0.020)和低密度脂蛋白胆固醇(r =-.243,P = 0.008)。肥胖、超重与spexin 结论:整体高血压的糖尿病前期患者和非糖尿病患者的循环spexin水平较低,且与超声心动图和血脂参数相关。我们的研究确定的spexin临界值可能是检测高血压的有用指标,并可提高临床医生对评估糖尿病前期患者高血压的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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