Cell-based therapy in the treatment of musculoskeletal diseases.

IF 5.4 2区 医学 Q1 CELL & TISSUE ENGINEERING
Justin Trapana, Jonathan Weinerman, Danny Lee, Anil Sedani, David Constantinescu, Thomas M Best, Francis J Hornicek, Joshua M Hare
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Abstract

A limited number of tissues can spontaneously regenerate following injury, and even fewer can regenerate to a state comparable to mature, healthy adult tissue. Mesenchymal stem cells (MSCs) were first described in the 1960s-1970s by Friedenstein et al as a small population of bone marrow cells with osteogenic potential and abilities to differentiate into chondrocytes. In 1991, Arnold Caplan coined the term "mesenchymal cells" after identifying these cells as a theoretical precursor to bone, cartilage, tendon, ligament, marrow stroma, adipocyte, dermis, muscle, and connective tissues. MSCs are derived from periosteum, fat, and muscle. Another attractive property of MSCs is their immunoregulatory and regenerative properties, which result from crosstalk with their microenvironment and components of the innate immune system. Collectively, these properties make MSCs potentially attractive for various therapeutic purposes. MSCs offer potential in sports medicine, aiding in muscle recovery, meniscal tears, and tendon and ligament injuries. In joint disease, MSCs have the potential for chondrogenesis and reversing the effects of osteoarthritis. MSCs have also demonstrated potential application to the treatment of degenerative disc disease of the cervical, thoracic, and lumbar spine.

治疗肌肉骨骼疾病的细胞疗法。
受伤后能自发再生的组织数量有限,能再生到与成熟、健康的成人组织相媲美的状态的组织更是少之又少。间充质干细胞(MSCs)最早由弗里登斯坦(Friedenstein)等人于20世纪60-70年代描述,是一小部分具有成骨潜能和分化为软骨细胞能力的骨髓细胞。1991 年,阿诺德-卡普兰(Arnold Caplan)在确定间充质细胞是骨、软骨、肌腱、韧带、骨髓基质、脂肪细胞、真皮、肌肉和结缔组织的理论前体后,创造了 "间充质细胞 "一词。间充质干细胞来源于骨膜、脂肪和肌肉。间充质干细胞的另一个诱人特性是其免疫调节和再生特性,这是与微环境和先天性免疫系统成分相互作用的结果。总之,这些特性使得间充质干细胞具有用于各种治疗目的的潜在吸引力。间充质干细胞在运动医学方面具有潜力,有助于肌肉恢复、半月板撕裂、肌腱和韧带损伤。在关节疾病方面,间充质干细胞具有软骨生成和逆转骨关节炎影响的潜力。间充质干细胞还具有治疗颈椎、胸椎和腰椎椎间盘退行性疾病的潜力。
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来源期刊
Stem Cells Translational Medicine
Stem Cells Translational Medicine CELL & TISSUE ENGINEERING-
CiteScore
12.90
自引率
3.30%
发文量
140
审稿时长
6-12 weeks
期刊介绍: STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.
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