Testing a Motor Score Based on PANSS Ratings: A Proxy for Comprehensive Motor Assessment.

IF 5.3 1区 医学 Q1 PSYCHIATRY
Niluja Nadesalingam, Alexandra Kyrou, Victoria Chapellier, Lydia Maderthaner, Sofie von Känel, Florian Wüthrich, Melanie G Nuoffer, Stephanie Lefebvre, Anastasia Pavlidou, Thomas Wobrock, Wolfgang Gaebel, Joachim Cordes, Berthold Langguth, Peter Falkai, Thomas Schneider-Axmann, Wolfgang Strube, Alkomiet Hasan, Sebastian Walther
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Abstract

Background and hypothesis: Abnormal psychomotor behavior is a core schizophrenia symptom. However, assessment of motor abnormalities with expert rating scales is challenging. The Positive and Negative Syndrome Scale (PANSS) includes 3 items broadly related to hypokinetic motor behavior. Here, we tested whether a sum score of the PANSS items mannerisms and posturing (G5), motor retardation (G7), and disturbance of volition (G13) corresponds to expert ratings, potentially qualifying as a proxy-marker of motor abnormalities.

Study design: Combining baseline datasets (n = 196) of 2 clinical trials (OCoPS-P, BrAGG-SoS), we correlated PANSS motor score (PANSSmot) and 5 motor rating scales. In addition, we tested whether the cutoff set at ≥3 on each PANSS motor item, ie, "mild" on G05, G07, and G13 (in total ≥9 on PANSSmot) would differentiate the patients into groups with high vs low scores in motor scales. We further sought for replication in an independent trial (RESIS, n = 102), tested the longitudinal stability using week 3 data of OCoPS-P (n = 75), and evaluated the validity of PANSSmot with instrumental measures of physical activity (n = 113).

Study results: PANSSmot correlated with all motor scales (Spearman-Rho-range 0.19-0.52, all P ≤ .007). Furthermore, the cutoff set at ≥3 on each PANSS motor item was able to distinguish patients with high vs low motor scores in all motor scales except using Abnormal Involuntary Movement Scale (Mann-Whitney-U-Tests: all U ≥ 580, P ≤ .017).

Conclusions: Our findings suggest that PANSSmot could be a proxy measure for hypokinetic motor abnormalities. This might help to combine large datasets from clinical trials to explore whether some interventions may hold promise to alleviate hypokinetic motor abnormalities in psychosis.

测试基于 PANSS 评分的运动评分:综合运动评估的替代方法
背景与假设:精神运动行为异常是精神分裂症的核心症状之一。然而,用专家评分量表来评估运动异常是一项挑战。积极与消极综合征量表(PANSS)包括 3 个与运动过少有关的项目。在此,我们测试了 PANSS 项目举止和姿势(G5)、运动迟缓(G7)和意志障碍(G13)的总分是否与专家评分一致,从而是否有可能作为运动异常的替代标记:研究设计:结合 2 项临床试验(OCoPS-P、BrAGG-SoS)的基线数据集(n = 196),我们将 PANSS 运动评分(PANSSmot)与 5 个运动评分量表进行了关联。此外,我们还测试了将 PANSS 各运动项目(即 G05、G07 和 G13 项上的 "轻度"(PANSSmot 项上总分≥9 分)设定为≥3 分的临界值是否能将患者区分为运动量表高分组和低分组。我们进一步寻求在一项独立试验(RESIS,n = 102)中进行复制,使用 OCoPS-P 第 3 周数据测试纵向稳定性(n = 75),并通过体育活动的工具测量评估 PANSSmot 的有效性(n = 113):研究结果:PANSSmot与所有运动量表都有相关性(Spearman-Rho-range 0.19-0.52,所有P≤.007)。此外,将 PANSS 各运动项目的分界点设定为≥3,除了使用异常不自主运动量表(Mann-Whitney-U-Tests:所有 U ≥580,P≤.017)外,在所有运动量表中都能区分运动得分高与运动得分低的患者:我们的研究结果表明,PANSSmot可以作为运动功能低下运动异常的替代测量指标。结论:我们的研究结果表明,PANSSmot可以作为运动功能减退运动异常的替代测量指标,这可能有助于结合临床试验的大型数据集,探讨某些干预措施是否有望缓解精神病患者的运动功能减退运动异常。
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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
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