The Association between Preserved Ratio Impaired Spirometry and Depression: Results from a Prospective Population-Based Study.

IF 3.5 3区医学 Q2 RESPIRATORY SYSTEM

Respiration Pub Date : 2024-09-02 DOI:10.1159/000541212

Ping Lin, Xiaoqian Li, Faming Jiang, Zongan Liang

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Abstract

Introduction: The relationship between preserved ratio impaired spirometry (PRISm) and depression remains unclear. This study aimed to assess the bidirectional relationship between PRISm and depression using data from a national cohort.

Methods: Data from wave 2 (2004-2005) to wave 4 (2008-2009) of the English Longitudinal Study of Ageing (ELSA) were analyzed. Lung function and depressive symptoms were measured at baseline and follow-up. Cox proportional hazard models were used to calculate the hazard ratio (HR) of PRISm with depression (study 1) and depression with PRISm (study 2).

Results: Studies 1 and 2 included 2,934 and 2,277 participants, respectively. The follow-up period extended from wave 2 to wave 4. In univariate analyses, a bidirectional association between PRISm and depression was observed, with unadjusted HRs of 1.49 (95% confidence interval [CI], 1.12-1.99; p = 0.007) in study 1 and 1.69 (95% CI, 1.13-2.52; p = 0.010) in study 2. However, in multivariable Cox models, baseline PRISm was not associated with subsequent depression development (adjusted HR 1.26; 95% CI, 0.94-1.69; p = 0.128). Conversely, participants with depression had a significantly higher risk of developing PRISm compared to those without depression (adjusted HR 1.54; 95% CI, 1.03-2.32; p = 0.038). These findings were consistent with z-score-based interpretive strategies, with an adjusted HR of 1.30 (95% CI, 0.95-1.77; p = 0.105) in study 1 and 1.59 (95% CI, 1.03-2.47; p = 0.038) in study 2.

Conclusions: Depression was associated with an increased risk of developing PRISm, whereas PRISm did not increase the risk of developing depression. Physicians should be vigilant for potential PRISm development in patients with depression.

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肺活量保留率受损与抑郁之间的关系：一项前瞻性人群研究的结果。

简介保留比值受损肺活量（PRISm）与抑郁症之间的关系仍不清楚。本研究旨在利用全国队列数据评估 PRISm 与抑郁症之间的双向关系：方法：分析了英国老龄化纵向研究（ELSA）第 2 波（2004-2005 年）至第 4 波（2008-2009 年）的数据。在基线和随访期间测量了肺功能和抑郁症状。采用 Cox 比例危险模型计算 PRISm 与抑郁症（研究 1）和抑郁症与 PRISm（研究 2）的危险比 (HR)：研究 1 和研究 2 分别纳入了 2,934 和 2,277 名参与者。随访期从第 2 波延长至第 4 波。在单变量分析中，观察到 PRISm 与抑郁之间存在双向关联，在研究 1 中，未经调整的 HR 值为 1.49（95% 置信区间 [CI]，1.12-1.99；P=0.007），在研究 2 中，未经调整的 HR 值为 1.69（95% 置信区间 [CI]，1.13-2.52；P=0.010）。然而，在多变量 Cox 模型中，基线 PRISm 与随后的抑郁发展无关（调整 HR 1.26；95% CI，0.94-1.69；P=0.128）。相反，与没有抑郁症的参与者相比，有抑郁症的参与者患 PRISm 的风险明显更高（调整后 HR 1.54；95% CI，1.03-2.32；P=0.038）。这些结果与基于 z 评分的解释策略一致，研究 1 的调整 HR 为 1.30（95% CI，0.95-1.77；P=0.105），研究 2 的调整 HR 为 1.59（95% CI，1.03-2.47；P=0.038）：抑郁症与 PRISm 的发病风险增加有关，而 PRISm 不会增加抑郁症的发病风险。医生应警惕抑郁症患者发生 PRISm 的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiration 医学-呼吸系统

CiteScore

7.30

自引率

5.40%

发文量

审稿时长

4-8 weeks

期刊介绍： ''Respiration'' brings together the results of both clinical and experimental investigations on all aspects of the respiratory system in health and disease. Clinical improvements in the diagnosis and treatment of chest and lung diseases are covered, as are the latest findings in physiology, biochemistry, pathology, immunology and pharmacology. The journal includes classic features such as editorials that accompany original articles in clinical and basic science research, reviews and letters to the editor. Further sections are: Technical Notes, The Eye Catcher, What’s Your Diagnosis?, The Opinion Corner, New Drugs in Respiratory Medicine, New Insights from Clinical Practice and Guidelines. ''Respiration'' is the official journal of the Swiss Society for Pneumology (SGP) and also home to the European Association for Bronchology and Interventional Pulmonology (EABIP), which occupies a dedicated section on Interventional Pulmonology in the journal. This modern mix of different features and a stringent peer-review process by a dedicated editorial board make ''Respiration'' a complete guide to progress in thoracic medicine.