Is X chromosome inactivation a cause or effect of SLE?

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-09-02 DOI:10.1038/s41584-024-01159-9

R. Hal Scofield, Valerie M. Lewis

引用次数: 0

Abstract

Autoimmune diseases such as systemic lupus erythematosus preferentially affect women, and multiple hypotheses are under investigation to elucidate this phenomenon. Emerging research suggests that multiple pathophysiological mechanisms and pathways are likely involved, including several that involve the X chromosome, but is skewing of X chromosome inactivation one of them?

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X 染色体失活是系统性红斑狼疮的原因还是结果？

系统性红斑狼疮等自身免疫性疾病主要影响女性，目前正在研究多种假说，以阐明这一现象。新的研究表明，可能涉及多种病理生理机制和途径，其中包括几种涉及 X 染色体的机制和途径，但 X 染色体失活偏斜是否是其中之一呢？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.