The interaction between PAX9 rs2073244 and passive smoking during pregnancy on low birth weight in newborns: a case-control study.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2024-09-03 DOI:10.1080/09603123.2024.2394625

Qun Lou, Sihan Wu, Jinhua Zhang, Rongzhen Xie, Xiaoqing Wu, Zhinan Guo, Youlan Chen

{"title":"The interaction between PAX9 rs2073244 and passive smoking during pregnancy on low birth weight in newborns: a case-control study.","authors":"Qun Lou, Sihan Wu, Jinhua Zhang, Rongzhen Xie, Xiaoqing Wu, Zhinan Guo, Youlan Chen","doi":"10.1080/09603123.2024.2394625","DOIUrl":null,"url":null,"abstract":"To explore whether rs2073244 at PAX9 increased susceptibility for full-term low birth weight infants and whether indoors passive smoking exposure has a combined effect with rs2073244 on newborn low birth weight (LBW), a 1:2 paired case-control study of LBW newborns was conducted at Xiamen University Affiliated Women and Children's Hospital from March 2010 to October 2013. The rate of indoor passive smoking exposure in the LBW group was higher than it in the NBW group (p = 0.019). GG of PAX9 rs2073244 decreased the risk of LBW [OR = 0.38, 95% CI: (0.15-0.98)] and smaller HC [OR = 0.44, 95% CI:(0.20-0.98)]. The relative excess risk for LBW contributed by the additive interaction between the rs2073244 risk genotypes AG/AA and mother pregnancy passive smoking exposure was 10.679 (95%CI 1.728-65.975). Our study suggested that the AG/AA genotype of PAX9 rs2073244 might be a risk factor for LBW of full-term newborns, especially in maternal passive smoking.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2024.2394625","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

To explore whether rs2073244 at PAX9 increased susceptibility for full-term low birth weight infants and whether indoors passive smoking exposure has a combined effect with rs2073244 on newborn low birth weight (LBW), a 1:2 paired case-control study of LBW newborns was conducted at Xiamen University Affiliated Women and Children's Hospital from March 2010 to October 2013. The rate of indoor passive smoking exposure in the LBW group was higher than it in the NBW group (p = 0.019). GG of PAX9 rs2073244 decreased the risk of LBW [OR = 0.38, 95% CI: (0.15-0.98)] and smaller HC [OR = 0.44, 95% CI:(0.20-0.98)]. The relative excess risk for LBW contributed by the additive interaction between the rs2073244 risk genotypes AG/AA and mother pregnancy passive smoking exposure was 10.679 (95%CI 1.728-65.975). Our study suggested that the AG/AA genotype of PAX9 rs2073244 might be a risk factor for LBW of full-term newborns, especially in maternal passive smoking.

查看原文本刊更多论文

PAX9 rs2073244 与孕期被动吸烟对新生儿低出生体重的交互作用：一项病例对照研究。

为了探讨PAX9的rs2073244是否会增加足月低出生体重儿的易感性，以及室内被动吸烟暴露是否与rs2073244对新生儿低出生体重（LBW）有联合影响，2010年3月至2013年10月，厦门大学附属妇女儿童医院对LBW新生儿进行了1:2配对病例对照研究。枸杞新生儿组的室内被动吸烟暴露率高于非枸杞新生儿组（P = 0.019）。PAX9 rs2073244的GG可降低枸杞婴的风险[OR = 0.38，95% CI：（0.15-0.98）]和较小HC的风险[OR = 0.44，95% CI：（0.20-0.98）]。rs2073244风险基因型AG/AA与母亲孕期被动吸烟暴露之间的相加交互作用导致的低体重儿相对超额风险为10.679（95%CI 1.728-65.975）。我们的研究表明，PAX9 rs2073244的AG/AA基因型可能是足月新生儿枸杞体重不足的一个风险因素，尤其是在母亲被动吸烟的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.

文献相关原料

公司名称	产品信息	采购帮参考价格