Regulation and Crosstalk of Cells and Factors in the Pancreatic Cancer Microenvironment.

IF 2.3 4区医学 Q3 ONCOLOGY

Current cancer drug targets Pub Date : 2024-09-02 DOI:10.2174/0115680096317840240723071018

Jia Xu, Songmei Lou, Hui Huang, Jian Xu, Feng Luo

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引用次数: 0

Abstract

Pancreatic cancer is a highly malignant form of cancer that distinguishes itself from other gastrointestinal tumors through significant fibrosis and unique perineural invasion. These characteristics underscore the complexity of neural regulation within the pancreatic cancer Tumor Microenvironment (TME). This review aimed to explore the regulatory mechanisms and crosstalk among stromal cells and their factors within the pancreatic cancer microenvironment. We begin by reviewing the major components of the pancreatic cancer microenvironment, analyzing interactions among crucial cell types, such as Cancer-associated Fibroblasts (CAFs) and immune cells, and revealing the dynamic changes between tumor cells and surrounding nerves, immune, and stromal cells. We discuss the role of neural factors, including the Nerve Growth Factor (NGF) and Brain-derived Neurotrophic Factor (BDNF), in the progression of pancreatic cancer and the mechanisms by which the sympathetic and parasympathetic nervous systems regulate tumor cell growth, migration, and invasion. Interactions among stromal cells, cytokines, and neural factors in the pancreatic cancer microenvironment promote fibrosis and perineural invasion. A deeper understanding of the regulation and crosstalk among components in the pancreatic cancer microenvironment offers new perspectives for inhibiting fibrosis and perineural invasion in pancreatic cancer.

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胰腺癌微环境中细胞和因子的调节与相互影响

胰腺癌是一种高度恶性的癌症，与其他胃肠道肿瘤的不同之处在于它有明显的纤维化和独特的神经周围侵袭。这些特点凸显了胰腺癌肿瘤微环境（TME）中神经调控的复杂性。本综述旨在探讨胰腺癌微环境中基质细胞及其因子之间的调控机制和相互影响。我们首先回顾了胰腺癌微环境的主要组成部分，分析了癌症相关成纤维细胞（CAF）和免疫细胞等关键细胞类型之间的相互作用，揭示了肿瘤细胞与周围神经、免疫细胞和基质细胞之间的动态变化。我们讨论了神经因子（包括神经生长因子（NGF）和脑源性神经营养因子（BDNF））在胰腺癌进展中的作用，以及交感和副交感神经系统调控肿瘤细胞生长、迁移和侵袭的机制。胰腺癌微环境中基质细胞、细胞因子和神经因子之间的相互作用会促进纤维化和神经周围侵袭。深入了解胰腺癌微环境中各成分之间的调节和相互影响为抑制胰腺癌的纤维化和会厌侵袭提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.