Ultrasmall Prussian Blue Nanozyme Attenuates Osteoarthritis by Scavenging Reactive Oxygen Species and Regulating Macrophage Phenotype.

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2024-09-18 Epub Date: 2024-09-03 DOI:10.1021/acs.nanolett.4c03314

Zhiguo Qin, Xiaofei Li, Peng Wang, Qian Liu, Yan Li, Aihua Gu, Qing Jiang, Ning Gu

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Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one of the crucial factors inducing the pathological progression of OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed by regulating the configuration of polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity and catalase-like activity, capable of decomposing hydrogen peroxide (H₂O₂) into O₂. The anti-inflammatory mechanism of USPBNPs can be attributed to repolarizing macrophages from pro-inflammatory M1 to anti-inflammatory M2 phenotype by decreasing the ROS levels accompanied by O₂ improvement. Additionally, USPBNPs exhibit an exciting therapeutic efficiency against OA, comparable to that of hydrocortisone in vivo. This study not only develops a new therapeutic agent for OA but also offers an estimable insight into the application of the nanozyme.

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超微普鲁士蓝纳米酶通过清除活性氧和调节巨噬细胞表型缓解骨关节炎

骨关节炎（OA）是一种退行性关节疾病，病因不明，治疗效果不理想，因此迫切需要开发新的高效疗法。过量活性氧（ROS）历来被认为是诱发 OA 病理进展的关键因素之一。超小普鲁士蓝纳米粒子（USPBNPs）通过调节聚乙烯吡咯烷酮链的构型研制而成，大小约为5纳米以下。USPBNPs 具有出色的消除 ROS 能力和类似催化剂的活性，能够将过氧化氢（H2O2）分解为 O2。USPBNPs 的抗炎机制可归因于通过降低 ROS 水平并改善 O2，使巨噬细胞从促炎的 M1 表型恢复到抗炎的 M2 表型。此外，USPBNPs 对 OA 具有令人兴奋的治疗效果，在体内可与氢化可的松相媲美。这项研究不仅开发了一种新的治疗 OA 的药物，还为纳米酶的应用提供了可估计的洞察力。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.