Illuminating GPCR trafficking

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-09-02 DOI:10.1038/s41589-024-01699-x

Michelle L. Halls

引用次数: 0

Abstract

A method to study G-protein-coupled receptor (GPCR) trafficking has been developed using engineered APEX2 and CRISPR interference screening. The innovative approach reveals a network of proteins coordinated by DNAJC13 that control efficient GPCR sorting into degradative or recycling pathways.

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阐明 GPCR 的贩运

利用工程化 APEX2 和 CRISPR 干扰筛选技术，开发出了一种研究 G 蛋白偶联受体（GPCR）贩运的方法。这种创新方法揭示了一个由 DNAJC13 协调的蛋白质网络，它控制着 GPCR 向降解或循环途径的高效分拣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

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