Activating the dark genome to illuminate cancer vaccine targets

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-02 DOI:10.1038/s41588-024-01850-3

Darwin W. Kwok, Hideho Okada, Joseph F. Costello

引用次数: 0

Abstract

Epigenetic therapy triggers myriad transposable elements to generate new antigens that could prime tumor cells for immunotherapy. A study of glioblastoma discovers indiscriminate activation in healthy cells as well, and presents a more selective strategy for potential therapeutic targeting.

Abstract Image

查看原文本刊更多论文

激活黑暗基因组，照亮癌症疫苗靶点

表观遗传疗法会触发无数可转座元件产生新的抗原，从而为肿瘤细胞的免疫疗法提供素材。对胶质母细胞瘤的研究发现，健康细胞中也存在不加区分的激活，这为潜在的靶向治疗提供了更具选择性的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution