Tailoring biomaterials for skin anti-aging

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-08-28 DOI:10.1016/j.mtbio.2024.101210

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Abstract

Skin aging is the phenomenon of degenerative changes in the structure and function of skin tissues over time and is manifested by a gradual loss of skin elasticity and firmness, an increased number of wrinkles, and hyperpigmentation. Skin anti-aging refers to a reduction in the skin aging phenomenon through medical cosmetic technologies. In recent years, new biomaterials have been continuously developed for improving the appearance of the skin through mechanical tissue filling, regulating collagen synthesis and degradation, inhibiting pigmentation, and repairing the skin barrier. This review summarizes the mechanisms associated with skin aging, describes the biomaterials that are commonly used in medical aesthetics and their possible modes of action, and discusses the application strategies of biomaterials in this area. Moreover, the synergistic effects of such biomaterials and other active ingredients, such as stem cells, exosomes, growth factors, and antioxidants, on tissue regeneration and anti-aging are evaluated. Finally, the possible challenges and development prospects of biomaterials in the field of anti-aging are discussed, and novel ideas for future innovations in this area are summarized.

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为皮肤抗衰老量身定制生物材料

皮肤衰老是指皮肤组织的结构和功能随着时间的推移发生退行性变化的现象，表现为皮肤弹性和紧致度逐渐减弱、皱纹增多和色素沉着。皮肤抗衰老是指通过医学美容技术减少皮肤衰老现象。近年来，人们不断开发新的生物材料，通过机械组织填充、调节胶原蛋白合成和降解、抑制色素沉着、修复皮肤屏障等方法改善皮肤外观。本综述总结了与皮肤老化相关的机制，介绍了医学美容中常用的生物材料及其可能的作用模式，并讨论了生物材料在这一领域的应用策略。此外，还评估了此类生物材料与干细胞、外泌体、生长因子和抗氧化剂等其他活性成分对组织再生和抗衰老的协同作用。最后，讨论了生物材料在抗衰老领域可能面临的挑战和发展前景，并总结了该领域未来创新的新思路。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).