Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma.

IF 3.7 Q1 CLINICAL NEUROLOGY
Neuro-oncology advances Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.1093/noajnl/vdae139
Santiago Cabezas-Camarero, Rebeca Pérez-Alfayate, Carmen Polidura, María Natividad Gómez-Ruiz, Lidia Gil-Martínez, Isabel Casado-Fariñas, Jorge Bartolomé, Pedro Pérez-Segura
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引用次数: 0

Abstract

FGFR3-TACC3 fusion-positive IDH-wild-type (IDH-WT) glioblastoma (GB) is a rare GB subtype occurring in approximately 3% of cases. It is clinical behavior and molecular profile is different from those of fusion-negative IDH-WT GBs. Evidence on the role of FGFR inhibitors in FGFR-altered gliomas is limited. We present the case of a patient with a FGFR3-TACC3 fusion-positive IDH-WT GB that at its second recurrence was treated with the FGFR inhibitor erdafitinib through a compassionate use program. Although no objective response was achieved, an overt deceleration in tumor growth was evidenced and the patient remained on treatment for 5.5 months.

厄达非替尼对FGFR3-TACC3融合阳性IDH野生型胶质母细胞瘤的持久疗效和肿瘤生长动态减缓
FGFR3-TACC3融合阳性的IDH-Wild型(IDH-WT)胶质母细胞瘤(GB)是一种罕见的GB亚型,发生率约为3%。它的临床表现和分子特征与融合阴性的 IDH-WT GB 不同。FGFR抑制剂在FGFR改变的胶质瘤中的作用证据有限。我们介绍了一例FGFR3-TACC3融合阳性IDH-WT GB患者的病例,该患者在第二次复发时通过同情使用计划接受了FGFR抑制剂erdafitinib的治疗。虽然没有取得客观反应,但肿瘤生长明显减速,患者继续治疗了5.5个月。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
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