Sodium Butyrate, a Gut Microbiota Derived Metabolite, in Type 2 Diabetes Mellitus and Cardiovascular Disease: A Review.

Cardiovascular & hematological agents in medicinal chemistry Pub Date : 2024-08-28 DOI:10.2174/0118715257307380240820052940

Zeynab Sarlak, Narges Naderi, Bardia Amidi, Vajihe Ghorbanzadeh

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Abstract

Type 2 diabetes is characterized by elevated blood glucose levels, leading to an increased risk of cardiovascular diseases. Sodium butyrate, the sodium salt of the short-chain fatty acid butyric acid produced by gut microbiota fermentation, has shown promising effects on metabolic diseases, including type 2 diabetes and cardiovascular diseases. Sodium butyrate demonstrates anti-inflammatory, anti-oxidative, and lipid-lowering properties and can improve insulin sensitivity and reduce hepatic steatosis. In this review, we investigate how sodium butyrate influences cardiovascular complications of type 2 diabetes, including atherosclerosis (AS), heart failure (HF), hypertension, and angiogenesis. Moreover, we explore the pathophysiology of cardiovascular disease in type 2 diabetes, focusing on hyperglycemia, oxidative stress, inflammation, and genetic factors playing crucial roles. The review suggests that sodium butyrate can be a potential preventive and therapeutic agent for cardiovascular complications in individuals with type 2 diabetes.

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丁酸钠--一种源自肠道微生物群的代谢物--在 2 型糖尿病和心血管疾病中的作用：综述。

2 型糖尿病的特点是血糖水平升高，导致罹患心血管疾病的风险增加。丁酸钠是肠道微生物群发酵产生的短链脂肪酸丁酸的钠盐，对代谢性疾病（包括 2 型糖尿病和心血管疾病）有很好的疗效。丁酸钠具有抗炎、抗氧化和降脂的特性，并能改善胰岛素敏感性和减轻肝脏脂肪变性。在这篇综述中，我们研究了丁酸钠如何影响 2 型糖尿病的心血管并发症，包括动脉粥样硬化（AS）、心力衰竭（HF）、高血压和血管生成。此外，我们还探讨了 2 型糖尿病心血管疾病的病理生理学，重点研究了起关键作用的高血糖、氧化应激、炎症和遗传因素。综述表明，丁酸钠是一种潜在的预防和治疗 2 型糖尿病患者心血管并发症的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cardiovascular & hematological agents in medicinal chemistry

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