RNA m⁶A methylation at the juxtaposition of apoptosis and RNA therapeutics.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI:10.1016/j.tcb.2024.08.002

Bünyamin Akgül, Azime Akçaöz-Alasar, Buket Sağlam

引用次数: 0

Abstract

Targeting RNA m⁶A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m⁶A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m⁶A marks.

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处于细胞凋亡和 RNA 治疗并列位置的 RNA m6A 甲基化。

以细胞凋亡相关转录本中的 RNA m6A 标记为靶点，有望实现 RNA 治疗。然而，促凋亡或抗凋亡转录本上的通路特异性 RNA m6A 位点尚未完全揭示，更不用说表征了。本文总结了目前在细胞凋亡刺激特异性 RNA m6A 标志调控细胞反应方面的知识和差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.

RNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics.

Abstract

RNA m⁶A methylation at the juxtaposition of apoptosis and RNA therapeutics.