The association of a low-inflammatory diet with the trajectory of multimorbidity: a large community-based longitudinal study

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-11-01 DOI:10.1016/j.ajcnut.2024.08.029

Maiwulamujiang Maimaitiyiming , Rongrong Yang , Huiying Da , Jiao Wang , Xiuying Qi , Yaogang Wang , Michelle M. Dunk , Weili Xu

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引用次数: 0

Abstract

Background

A proinflammatory diet has been associated with a risk of individual chronic diseases, however, evidence on the association between inflammatory dietary patterns and the trajectory of chronic disease multimorbidity is sparse.

Objectives

We aimed to investigate the associations of a low-inflammatory diet with the multimorbidity trajectory.

Methods

Within the UK Biobank, 102,424 chronic disease-free participants (mean age 54.7 ± 7.9 y, 54.8% female) were followed up to detect multimorbidity trajectory (annual change in the number of 59 chronic diseases). Baseline inflammatory diet index (IDI) and empirical dietary inflammatory pattern (EDIP) were separately calculated from the weighted sum of 32 posteriori-derived (15 anti-inflammatory) and 18 prior-defined (9 anti-inflammatory) food groups, and tertiled as low-, moderate-, and high-inflammatory diet. Data were analyzed using linear mixed effects model, Cox model, and Laplace regression with adjustment for potential confounders.

Results

During the follow-up (median 10.23 y), 15,672 and 35,801 participants developed 1 and 2+ chronic conditions, respectively. Adherence to a low-inflammatory diet was associated with decreased multimorbidity risk (hazard ratio [HR_IDI] = 0.84, 95% confidence interval [CI]: 0.81, 0.86; HR_EDIP = 0.91, 95% CI: 0.89, 0.94) and a slower multimorbidity accumulation (β_IDI = −0.033, 95% CI: −0.036, −0.029; β_EDIP = −0.006, 95% CI: −0.010, −0.003) compared with a high-inflammatory diet, especially in participants aged > 60 y (β_IDI = −0.051, 95% CI: −0.059, −0.042; β_EDIP = −0.020, 95% CI: −0.029, −0.012; both P-interactions < 0.05). The 50th percentile difference (95% CI) of chronic disease-free survival time was prolonged by 0.81 (0.64, 0.97) and 0.49 (0.34, 0.64) y for participants with a low IDI and EDIP, respectively. Higher IDI and EDIP were associated with the development of 4 and 3 multimorbidity clusters (especially for cardiometabolic diseases), respectively.

Conclusions

A low-inflammatory diet is associated with a lower risk and slower accumulation of multimorbidity (especially in participants aged > 60 y). A low-inflammatory diet may prolong chronic disease-free survival time.

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低炎性饮食与多病症轨迹的关联：一项大型社区纵向研究。

背景：促炎性饮食与个别慢性疾病的风险有关，但有关炎性饮食模式与慢性疾病多病化轨迹之间关系的证据却很少：我们旨在研究低炎症性饮食与多病症发病轨迹之间的关系：方法：在英国生物数据库中，对102424名无慢性疾病的参与者（平均年龄为54.7±7.9岁，54.8%为女性）进行随访，以检测多病性轨迹（59种慢性疾病数量的年度变化）。基线炎症膳食指数（IDI）和经验膳食炎症模式（EDIP）分别由32种后验（15种抗炎）和18种先验（9种抗炎）食物组的加权和计算得出，并分为低、中、高炎症膳食。数据采用线性混合效应模型、Cox 模型和拉普拉斯回归进行分析，并对潜在的混杂因素进行了调整：在随访期间（中位数为 10.23 年），分别有 15672 名和 35801 名参与者患上了 1 种和 2 种以上慢性疾病。坚持低炎性饮食与多病风险的降低有关（危险比 [HRIDI]=0.84, 95% 置信区间 [CI]：0.81，0.86；HREDIP=0.91，95% 置信区间[CI]：0.89，0.94），多病累积速度较慢（βID=-0.033，95% 置信区间[CI]：-0.036，-0.029；βEDIP=-0.006，95% 置信区间[CI]：-0.010，-0.003）相比，尤其是在年龄大于 60 岁的参与者中（βDIDI=-0.051，95% CI：-0.059，-0.042；βEDIP=-0.020，95% CI：-0.029，-0.012；均为 P-交互作用）：低炎性饮食与多病风险较低和累积较慢有关（尤其是年龄大于 60 岁的参与者）。低炎饮食可延长无慢性疾病生存时间。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.