Charlotte Vadon, Maria Magda Magiera, Andrea Cimarelli
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引用次数: 0
Abstract
TRIM proteins are a family of innate immune factors that play diverse roles in innate immunity and protect the cell against viral and bacterial aggression. As part of this special issue on TRIM proteins, we will take advantage of our findings on TRIM69, which acts by reorganizing the microtubules (MTs) in a manner that is fundamentally antiviral, to more generally discuss how host-pathogen interactions that take place for the control of the MT network represent a crucial facet of the struggle that opposes viruses to their cell environment. In this context, we will present several other TRIM proteins that are known to interact with microtubules in situations other than viral infection, and we will discuss evidence that may suggest a possible contribution to viral control. Overall, the present review will highlight the importance that the control of the microtubule network bears in host-pathogen interactions.
TRIM 蛋白是先天性免疫因子家族的一员，在先天性免疫中发挥着多种作用，保护细胞免受病毒和细菌的侵袭。作为本期 TRIM 蛋白特刊的一部分，我们将利用我们对 TRIM69 的研究成果（TRIM69 通过重组微管（MT）的方式从根本上起到抗病毒作用），更广泛地讨论宿主与病原体之间如何通过控制 MT 网络进行互动，这是病毒与其细胞环境斗争的一个重要方面。在此背景下，我们将介绍已知在病毒感染以外的情况下与微管相互作用的其他几种 TRIM 蛋白，并将讨论可能有助于病毒控制的证据。总之，本综述将强调微管网络控制在宿主与病原体相互作用中的重要性。
期刊介绍：
Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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