Tirzepatide administration improves cognitive impairment in HFD mice by regulating the SIRT3-NLRP3 axis.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2024-09-02 DOI:10.1007/s12020-024-04013-w

Jingjing Ma, Yuanyuan Liu, Junya Hu, Xingjing Liu, Yin Xia, Wenqing Xia, Ziyang Shen, Xiaocen Kong, Xia Wu, Li Mao, Qian Li

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引用次数: 0

Abstract

Purpose: High-fat diet (HFD) currently is reported that in connection with cognitive impairment. Tirzepatide is a novel dual receptor agonist for glycemic control. But whether Tirzepatide exerts a protective effect in HFD-related cognitive impairment remains to be explore.

Methods: During the study, the cognitive dysfunction mice model induced by HFD were established. The expressions synapse-associated protein and other target proteins were detected. The oxidative stress parameters, levels of inflammatory cytokine were also detected.

Results: Our findings proved that Tirzepatide administration attenuates high fat diet-related cognitive impairment. Tirzepatide administration suppresses microglia activation, alleviates oxidative stress as well as suppressed the expression of NLRP3 in HFD mice by up-regulating SIRT3 expression. In conclusion, Tirzepatide attenuates HFD-induced cognitive impairment through reducing oxidative stress and neuroinflammation via SIRT3-NLRP3 signaling.

Conclusion: This study suggest that Tirzepatide has neuroprotective effects in HFD-related cognitive dysfunction mice model, which provides a promising treatment of HFD-related cognitive impairment.

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通过调节 SIRT3-NLRP3 轴，服用替扎帕肽可改善高脂蛋白血症小鼠的认知障碍。

目的：目前有报道称，高脂饮食（HFD）与认知障碍有关。替扎帕肽是一种新型的双受体激动剂，可用于控制血糖。但替哌肽是否对高脂饮食相关认知障碍具有保护作用仍有待探索：方法：本研究建立了高密度脂蛋白胆固醇（HFD）诱导的认知功能障碍小鼠模型。方法：研究过程中，建立了 HFD 诱导的认知功能障碍小鼠模型，检测了突触相关蛋白和其他靶蛋白的表达。研究结果表明，噻唑哌啶对小鼠的认知功能障碍有一定的抑制作用：结果：我们的研究结果证明，服用替扎帕肽可减轻与高脂饮食相关的认知障碍。通过上调 SIRT3 的表达，服用替扎帕肽可抑制小胶质细胞的活化、减轻氧化应激以及抑制高脂饮食小鼠 NLRP3 的表达。总之，替西帕肽通过SIRT3-NLRP3信号传导，减轻氧化应激和神经炎症，从而减轻HFD诱导的认知障碍：本研究表明，替扎帕肽对HFD相关认知功能障碍小鼠模型具有神经保护作用，有望用于治疗HFD相关认知功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.