Thyroid hormones for euthyroid patients with simple goiter growing over time: a survey of European thyroid specialists.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2025-01-01 Epub Date: 2024-08-31 DOI:10.1007/s12020-024-04002-z

Enrico Papini, Roberto Attanasio, Miloš Žarković, Endre Vezekenyi Nagy, Roberto Negro, Petros Perros, Juan Carlos Galofré, Chagit Adler Cohen, Ersin Akarsu, Maria Alevizaki, Göksun Ayvaz, Tomasz Bednarczuk, Biljana Nedeljković Beleslin, Eszter Berta, Miklos Bodor, Anna Maria Borissova, Mihail Boyanov, Camille Buffet, Maria-Cristina Burlacu, Jasmina Ćirić, Juan J Díez, Harald Dobnig, Valentin Fadeyev, Benjamin C T Field, Dagmar Führer-Sakel, Tommi Hakala, Jan Jiskra, Peter Andreas Kopp, Michael Krebs, Michal Kršek, Mikael Lantz, Ivica Lazúrová, Laurence Leenhardt, Vitaliy Luchytskiy, Francisca Marques Puga, Anne McGowan, Miguel Melo, Saara Metso, Carla Moran, Tatyana Morgunova, Dan Alexandru Niculescu, Božidar Perić, Tereza Planck, Eyal Robenshtok, Patrick Olivier Rosselet, Marek Ruchala, Kamilla Ryom Riis, Alla Shepelkevich, Mykola Tronko, David Unuane, Irfan Vardarli, W Edward Visser, Andromachi Vryonidou, Younes Ramazan Younes, Laszlo Hegedüs

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引用次数: 0

Abstract

Background: Treatment of simple goiter (SG) growing over time with thyroid hormone (TH) therapy is discouraged by international guidelines.

Purpose: To ascertain views of European thyroid specialists about TH treatment for euthyroid patients with growing SG and explore associations with management choice.

Methods: Online survey on the use of TH for growing SG among thyroid experts from 28 European countries.

Results: The response rate was 31.5% (5430/17,247). Most respondents were endocrinologists. Twenty-eight percent asserted that TH therapy may be indicated in euthyroid patients with a growing SG. National and regional differences were noted, from 7% of positive responses in The Netherlands to 78% in Czech Republic (p < 0.0001). TH was more frequently prescribed by respondents over 40 years old (OR 1.77, 2.13, 2.41 if 41-50, 51-60, >60, respectively), and working in areas of former iodine insufficiency (OR 1.24, 95% CI 1.03-1.50). TH was less frequently prescribed by endocrinologists (OR 0.77, 95% CI 0.62-0.94) and respondents working in Southern Europe (OR 0.40, 95% CI 0.33-0.48), Northern Europe (OR 0.28, 95% CI 0.22-0.36) and Western Asia (OR 0.16, 95% CI 0.11-0.24) compared to Western Europe. Associations with respondents' sex, country, availability of national thyroid guidelines, and gross national income per capita were absent or weak.

Conclusions: Almost a third of European thyroid specialists support treating SG with TH, contrary to current guidelines and recommendations. This calls for urgent attention.

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针对单纯性甲状腺肿长期增长的甲状腺功能正常患者的甲状腺激素：欧洲甲状腺专家调查。

背景：目的：了解欧洲甲状腺专家对生长型甲状腺肿（SG）甲状腺功能亢进患者使用甲状腺激素（TH）治疗的看法，并探讨其与治疗选择的关系：方法：对来自 28 个欧洲国家的甲状腺专家进行在线调查，了解对生长型 SG 患者使用 TH 治疗的情况：结果：回复率为31.5%（5430/17247）。大多数受访者为内分泌专家。28%的受访者认为，TH疗法适用于SG不断增大的甲状腺功能亢进患者。国家和地区之间存在差异，从荷兰的 7% 积极响应到捷克共和国的 78%（分别为 p 60），并且在以前碘不足的地区工作（OR 1.24，95% CI 1.03-1.50）。与西欧相比，内分泌科医生（OR 0.77，95% CI 0.62-0.94）和在南欧（OR 0.40，95% CI 0.33-0.48）、北欧（OR 0.28，95% CI 0.22-0.36）和西亚（OR 0.16，95% CI 0.11-0.24）工作的受访者较少处方 TH。与受访者的性别、国家、是否有国家甲状腺指南以及人均国民总收入没有关联或关联较弱：近三分之一的欧洲甲状腺专家支持用TH治疗SG，这与当前的指南和建议背道而驰。这需要引起紧急关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.