Investigation of the effect of intravitreal bevacizumab treatment on left heart function using speckle tracking echocardiography.

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Revista Portuguesa De Cardiologia Pub Date : 2024-08-30 DOI:10.1016/j.repc.2024.07.006

Mehmet Şahinbaş, İdris Buğra Çerik, Duygu Yalınbaş Yeter

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引用次数: 0

Abstract

Introduction and objectives: Vascular endothelial growth factor (VEGF) inhibitors are widely used in oncology and ophthalmology. Although these agents have been shown to increase the risk of cardiovascular events in systemic use, the effect of local applications is unclear. In our study, we aimed to investigate the effects of anti-VEGF agents on left heart functions after intravitreal injection using speckle tracking echocardiography.

Methods: In this prospectively designed study, 44 patients who were going to start intravitreal anti-VEGF treatment were included in the study. Patients were evaluated with speckle tracking echocardiography before the first anti-VEGF administration and at three months of anti-VEGF treatment.

Results: Global longitudinal strain (GLS) values at three months were lower in the patients who participated in the study and this was statistically significant (-18.77±2.17, -18.60±2.01, p=0.001). Also, there was a statistically significant decrease in the mean values of GLS (GLS4CH) obtained from apical four space image, GLS (GLSAPLAX) obtained from apical long axis image and GLS (GLS2CH) obtained from apical 2 space image at month 0 and month 3 (-19.08±2.39, -18.93±2.26, p=0.004; -18.81±2.29, -18.60±2.12, p=0.001; -18.44±2.31, -18.27±2.12, p=0.013, respectively).

Conclusion: The slight decrease in GLS in our study suggests that the use of intravitreal anti-VEGF agents may have cardiac effects.

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使用斑点追踪超声心动图研究玻璃体内贝伐单抗治疗对左心功能的影响。

导言和目标：血管内皮生长因子（VEGF）抑制剂广泛应用于肿瘤学和眼科学。虽然这些药物在全身使用时会增加心血管事件的风险，但局部应用的影响尚不清楚。在我们的研究中，我们旨在使用斑点追踪超声心动图研究抗血管内皮生长因子药物在玻璃体内注射后对左心功能的影响：在这项前瞻性设计的研究中，44 名即将开始接受玻璃体内抗血管内皮生长因子治疗的患者被纳入研究。患者在首次注射抗血管内皮生长因子前和接受抗血管内皮生长因子治疗三个月后接受斑点追踪超声心动图评估：结果：参与研究的患者三个月后的整体纵向应变（GLS）值较低，且具有统计学意义（-18.77±2.17，-18.60±2.01，P=0.001）。此外，在第 0 个月和第 3 个月，从根尖四间隙图像获得的 GLS（GLS4CH）、从根尖长轴图像获得的 GLS（GLSAPLAX）和从根尖二间隙图像获得的 GLS（GLS2CH）的平均值均有统计学意义的下降（-19.08±2.39，-18.93±2.26，p=0.004；-18.81±2.29，-18.60±2.12，p=0.001；-18.44±2.31，-18.27±2.12，p=0.013）：本研究中 GLS 的轻微下降表明，使用玻璃体内抗 VEGF 药物可能会对心脏产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Portuguesa De Cardiologia CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.70

自引率

22.20%

发文量

205

审稿时长

54 days

期刊介绍： The Portuguese Journal of Cardiology, the official journal of the Portuguese Society of Cardiology, was founded in 1982 with the aim of keeping Portuguese cardiologists informed through the publication of scientific articles on areas such as arrhythmology and electrophysiology, cardiovascular surgery, intensive care, coronary artery disease, cardiovascular imaging, hypertension, heart failure and cardiovascular prevention. The Journal is a monthly publication with high standards of quality in terms of scientific content and production. Since 1999 it has been published in English as well as Portuguese, which has widened its readership abroad. It is distributed to all members of the Portuguese Societies of Cardiology, Internal Medicine, Pneumology and Cardiothoracic Surgery, as well as to leading non-Portuguese cardiologists and to virtually all cardiology societies worldwide. It has been referred in Medline since 1987.