Oral manifestations of peripheral T cell lymphoma, not otherwise specified: case series and review of the current literature.

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-08-17 DOI:10.1016/j.oooo.2024.08.011

Eduardo Morato de Oliveira, Cinthia Veronica Bardález Lopéz de Cáceres, Carla Isabelly Fernandes-Rodrigues, Paulo Victor Mendes Penafort, Juan Manuel Arteaga Legarrea, Nathalia Rodrigues Gomes, Hélder Antônio Rebelo Pontes, Pablo Agustin Vargas, José Narciso Rosa Assunção Júnior, Ciro Dantas Soares, Felipe Paiva Fonseca

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引用次数: 0

Abstract

Objective: The objective of this study was to describe a series of peripheral T-cell lymphoma, not otherwise specified (PTCL NOS) affecting the oral cavity and to review the available literature.

Study design: Cases diagnosed as PTCL-NOS affecting the oral cavity were retrospectively retrieved from pathology files. Original hematoxylin and eosin-stained slides and immunohistochemical reactions were reviewed for microscopic confirmation. The presence of Epstein-Barr virus (EBV) was investigated by in situ hybridization. Clinical and follow-up data were retrieved from patients' pathology and medical files.

Results: A total of 5 cases were obtained with a mean age of 51.8 years old, 3 male patients and 2 female patients. Three cases affected the palate and 2 cases affected the gingiva, whereas 1 case affected the maxillary bone. Tumors presented as destructive, infiltrative, and painful lesions causing swelling, ulceration, and tissue necrosis. All cases exhibited CD3 expression. GATA3 was expressed in 3 cases. Four patients were deceased of the disease during follow-up.

Conclusions: PTCL NOS affecting the oral cavity is rare and usually present as a very aggressive disease, associated with a poor prognosis and dismal outcome. (Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).

查看原文本刊更多论文

非特异性外周 T 细胞淋巴瘤的口腔表现：病例系列和现有文献综述。

研究目的本研究旨在描述一系列影响口腔的外周T细胞淋巴瘤（PTCL NOS），并回顾现有文献：研究设计：从病理档案中回顾性检索被诊断为影响口腔的外周T细胞淋巴瘤（PTCL-NOS）的病例。对苏木精和伊红染色的原始切片及免疫组化反应进行复查，以进行显微镜确认。通过原位杂交检查是否存在 Epstein-Barr 病毒（EBV）。临床和随访数据来自患者的病理和医疗档案：共发现 5 例病例，平均年龄为 51.8 岁，其中 3 例为男性，2 例为女性。其中 3 例罹患上颚，2 例罹患牙龈，1 例罹患上颌骨。肿瘤表现为破坏性、浸润性和疼痛性病变，导致肿胀、溃疡和组织坏死。所有病例都有 CD3 表达。3例患者有GATA3表达。4例患者在随访期间因病死亡：结论：影响口腔的 PTCL NOS 很罕见，通常表现为侵袭性很强的疾病，预后差，结局悲惨。(Oral Surg Oral Med Oral Pathol Oral Radiol YEAR;VOL:page range).

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.